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    1. Structural Biology and Molecular Biophysics

    The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications

    Ahmad Abdelzaher Zaki Khalifa et al.
    A structure of the ciliary inner junction at 3.6 Å resolution permits atomic modeling of six inner junction proteins and their interactions with acetylated lysine 40 loops of alpha tubulins.
    1. Developmental Biology

    Cilia-mediated Hedgehog signaling controls form and function in the mammalian larynx

    Jacqueline M Tabler et al.
    Genetic studies in mice reveal the molecular and embryological mechanisms of vocal fold development and function, thereby informing our understanding of vocal communication and congenital voice defects.
    1. Cell Biology
    2. Neuroscience

    TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons

    Emily Bowie, Sarah C Goetz
    Signaling at the primary cilium is important to sustain the morphology, connectivity, and survival of a key neural population within the brain.
    1. Cell Biology

    A novel biosensor to study cAMP dynamics in cilia and flagella

    Shatanik Mukherjee et al.
    A new FRET-based cAMP biosensor with nanomolar sensitivity makes it possible to measure cAMP dynamics in miniscule subcellular compartments like cilia and flagella.
    1. Developmental Biology
    2. Human Biology and Medicine

    T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number

    Uchenna Emechebe et al.
    The transcription and splicing factor T-box3 is present in primary cilia, regulates multiple aspects of limb development, and interacts with members of the protein complex required for the stability and processing of the Gli3 transcription factor.
    1. Physics of Living Systems
    2. Cell Biology

    Dynamic curvature regulation accounts for the symmetric and asymmetric beats of Chlamydomonas flagella

    Pablo Sartori et al.
    The self-organised beat of cilia and flagella is dynamically regulated by curvature.
    1. Cell Biology

    Single molecule imaging reveals a major role for diffusion in the exploration of ciliary space by signaling receptors

    Fan Ye et al.
    Membrane receptor proteins move through primary cilia largely by passive diffusion rather than by active intraflagellar transport.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the polycystin 2-l1 ion channel

    Raymond E Hulse et al.
    The selectivity characteristics of PC-2L1, which make it a principal source of calcium in primary cilia function, is presented and advances understanding of the similarity and differences of TRPP ion channels.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly

    Hiroshi Yamaguchi et al.
    Zebrafish genetics and cryo-electron tomography reveal distinct roles of all vertebrate PIH family proteins in axonemal dynein assembly and cilia/flagella motions, assigning specific dynein subtypes to each PIH protein.
    1. Cell Biology

    A liquid-like organelle at the root of motile ciliopathy

    Ryan L Huizar et al.
    DynAPs reveal that biological phase separation provides the organizing principle for the complex process of dynein motor assembly in cells with motile cilia.