312 results found
  1. Point of View: What does it take to recruit and retain senior women faculty?

    Fiona M Watt
    eLife deputy editor Fiona M Watt recounts some of her personal experiences as a senior female academic in a male-dominated environment.
    1. Neuroscience

    The CNS connectome of a tadpole larva of Ciona intestinalis (L.) highlights sidedness in the brain of a chordate sibling

    Kerrianne Ryan et al.
    Serial-section EM analysis uncovers the CNS connectome of a Ciona larva, the second of any entire nervous system, and exposes left-right asymmetries in its synaptic circuits.
    1. Computational and Systems Biology

    Inferring genetic interactions from comparative fitness data

    Kristina Crona et al.
    A new mathematical approach can infer higher order genetic interactions from pairwise fitness comparisons between genotypes.
    1. Developmental Biology

    Reciprocal and dynamic polarization of planar cell polarity core components and myosin

    Erin Newman-Smith et al.
    Planar cell polarity (PCP) components and myosin show a parallel temporal polarization in the Ciona notochord and the mutual interaction between these proteins is required for proper tissue-wide polarity.
    1. Developmental Biology

    An FGF-driven feed-forward circuit patterns the cardiopharyngeal mesoderm in space and time

    Florian Razy-Krajka et al.
    A gene network for heart versus head muscle specification has been identified in the tunicate Ciona.
  2. Fiona Watt: Thank you, eLife

    As Fiona Watt steps down as eLife’s third Deputy Editor, she reflects on the achievements of the initiative to date.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A unifying mechanism for the biogenesis of membrane proteins co-operatively integrated by the Sec and Tat pathways

    Fiona J Tooke et al.
    Bioinformatics and experimental approaches identify families of membrane proteins requiring the co-ordinated action of the Sec pathway and Tat pathways for their integration and define features of the polypeptides that mediate interaction with these pathways.
    1. Microbiology and Infectious Disease

    RNA virus attenuation by codon pair deoptimisation is an artefact of increases in CpG/UpA dinucleotide frequencies

    Fiona Tulloch et al.
    Attenuating candidate live virus vaccines by incorporating unfavoured codon pairs to reduce translation efficiency is actually mediated though changes in frequencies of CpG and UpA dinucleotides, which make viruses more visible to the innate immune system.
    1. Developmental Biology

    The Natural History of Model Organisms: An organismal perspective on C. intestinalis development, origins and diversification

    Matthew J Kourakis, William C Smith
    The life cycle and morphology of the sea squirt Ciona intestinalis shed light on vertebrate evolution.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Assembly and positioning of actomyosin rings by contractility and planar cell polarity

    Ivonne M Sehring et al.
    Contractility wins over the polarity pathway in a tug-of-war to position a cytokinesis-like actomyosin ring at the equator of notochord cells.

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