21 results found
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    An internal thioester in a pathogen surface protein mediates covalent host binding

    Miriam Walden, John M Edwards ... Ulrich Schwarz-Linek
    Bacterial-encoded covalent adhesion is a new molecular principle in host-microbe interactions and may play a key role in host colonization by a wide range of Gram-positive bacteria.
    1. Microbiology and Infectious Disease

    C. difficile may be overdiagnosed in adults and is a prevalent commensal in infants

    Pamela Ferretti, Jakob Wirbel ... Peer Bork
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Major genetic discontinuity and novel toxigenic species in Clostridioides difficile taxonomy

    Daniel R Knight, Korakrit Imwattana ... Thomas V Riley
    The Clostridioides difficile taxonomy is characterised by major taxonomic incoherence and clear species boundaries.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Single-molecule analysis of the entire perfringolysin O pore formation pathway

    Conall McGuinness, James C Walsh ... Till Böcking
    Arc-shaped PFO oligomers consisting of at least four subunits can insert into the membrane in a kinetically controlled process opening a transmembrane pore, whereby post-insertion growth may ultimately lead to formation of a complete ring.
    1. Cell Biology
    2. Neuroscience

    Tissue-specific O-GlcNAcylation profiling identifies substrates in translational machinery in Drosophila mushroom body contributing to olfactory learning

    Haibin Yu, Dandan Liu ... Kai Yuan
    Brain region-specific profiling of O-GlcNAcylation interactome in Drosophila mushroom body suggests that hypo-O-GlcNAcylation impacts cognitive function by regulating translational activity.
    1. Microbiology and Infectious Disease

    Bacillus velezensis HBXN2020 alleviates Salmonella Typhimurium infection in mice by improving intestinal barrier integrity and reducing inflammation

    Linkang Wang, Haiyan Wang ... Ping Qian
    Bacillus velezensis has broad-spectrum antibacterial activity and can reduce the colonization of Salmonella Typhimurium in the intestinal tract of mice.
    1. Microbiology and Infectious Disease

    Gut bacteria are rarely shared by co-hospitalized premature infants, regardless of necrotizing enterocolitis development

    Tali Raveh-Sadka, Brian C Thomas ... Jillian F Banfield
    Rapid yet comprehensive, genome-resolved analysis of fecal samples from premature infants reveals little overlap in strain composition of gut microbial communities, despite co-hospitalization, and suggests the existence of barriers to strain dispersal.
    1. Structural Biology and Molecular Biophysics

    Single molecule compression reveals intra-protein forces drive cytotoxin pore formation

    Daniel M Czajkowsky, Jielin Sun ... Zhifeng Shao
    Compressive force spectroscopy of single molecules reveals that intra-protein forces underlie the long-distance coordination of structural changes within a cytotoxin during pore formation.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A selective gut bacterial bile salt hydrolase alters host metabolism

    Lina Yao, Sarah Craven Seaton ... A Sloan Devlin
    The deletion of a single gene encoding a selective bile salt hydrolase from the abundant human gut bacterium Bacteroides thetaiotaomicron significantly alters host metabolism.
    1. Neuroscience

    Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior

    Mar Gacias, Sevasti Gaspari ... Patrizia Casaccia
    Gut microbiota can influence mPFC transcriptional profiles and myelin content, overriding the impact of genetic background in the development of social avoidance behavior.

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