8,441 results found
    1. Neuroscience

    Science Forum: Ten common statistical mistakes to watch out for when writing or reviewing a manuscript

    Tamar R Makin, Jean-Jacques Orban de Xivry
    What can authors and reviewers do to keep common statistical mistakes out of the literature?
    1. Evolutionary Biology

    The last common ancestor of animals lacked the HIF pathway and respired in low-oxygen environments

    Daniel B Mills et al.
    Sponges and ctenophores lack hypoxia-inducible factors, suggesting that the metazoan last common ancestor could have lived aerobically under severe hypoxia and did not need to regulate its transcription in response to oxygen availability.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Hsp70-associated chaperones have a critical role in buffering protein production costs

    Zoltán Farkas et al.
    Protein biosynthesis and protein quality control jointly determine protein production costs.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Two locus inheritance of non-syndromic midline craniosynostosis via rare SMAD6 and common BMP2 alleles

    Andrew T Timberlake et al.
    Epistatic interactions of rare loss of function mutations in SMAD6 and a common variant modifier near BMP2 are the most common cause of midline craniosynostosis in humans.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Common activation mechanism of class A GPCRs

    Qingtong Zhou et al.
    Contrary to previous findings, class A GPCRs share a common activation pathway that directly links ligand binding to G-protein activation, as revealed by novel quantitative analysis.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Potential impact of outpatient stewardship interventions on antibiotic exposures of common bacterial pathogens

    Christine Tedijanto et al.
    Antibiotic stewardship in the outpatient setting can substantially reduce exposures of potential pathogens to common antibiotics, and complementary efforts are needed to reduce remaining exposures that occur in 'necessary' contexts.
    1. Neuroscience

    A common directional tuning mechanism of Drosophila motion-sensing neurons in the ON and in the OFF pathway

    Juergen Haag et al.
    A common mechanism for computation of direction selectivity in the ON and OFF channel is demonstrated.
    1. Neuroscience

    A common mechanism underlies changes of mind about decisions and confidence

    Ronald van den Berg et al.
    Initial confidence and choice in a decision, and their potential revision, arise from a common mechanism that challenges models that claim confidence and decision processes are dissociated.
  1. What it costs to publish

    We share full details of eLife's costs with the hope that, by being transparent, it will help to set a future course for research communication that is efficient and sustainable.
  2. Dollar notes resting on infrastructure diagram

    The running costs of eLife 2.0

    Paul Shannon, Head of Technology, looks at the costs of running eLife’s own continuous publication platform four months after the launch of eLife 2.0.

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