17 results found
    1. Developmental Biology
    2. Evolutionary Biology

    Evolution of the head-trunk interface in tetrapod vertebrates

    Elizabeth M Sefton et al.
    Both gill musculature and the evolutionarily conserved cucullaris muscle are derived from unsegmented mesoderm adjacent to the first 3 somites, extending the posterior limit of cranial mesoderm.
    1. Developmental Biology

    Notochord: Patterning the spine

    Matthew P Harris, Gloria Arratia
    Experiments have shed new light on the development of the spine in zebrafish.
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    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Non-classical amine recognition evolved in a large clade of olfactory receptors

    Qian Li et al.
    Fish trace amine-associated receptors evolved a novel structural motif that enables the detection of chemically diverse amine odors in a non-canonical 'inverted' orientation.
    1. Biochemistry and Chemical Biology
    2. Ecology

    De novo synthesis of a sunscreen compound in vertebrates

    Andrew R Osborn et al.
    Many vertebrates are able to synthesize a sunscreen compound de novo and the pathway involved can be used for heterologous production of the compound in yeast.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Regulation by the quorum sensor from Vibrio indicates a receptor function for the membrane anchors of adenylate cyclases

    Stephanie Beltz et al.
    A canonical class III adenylate cyclase with a membrane anchor of six transmembrane spans is regulated by a receptor of similar design, the quorum-sensing receptor from Vibrio harveyi.
    1. Cell Biology
    2. Developmental Biology

    Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2

    Pierluigi Scerbo et al.
    Degradation and asymmetric inheritance during cell division of a core pluripotency regulator contributes to lineage commitment in the early Xenopus embryo.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Predicting effective microRNA target sites in mammalian mRNAs

    Vikram Agarwal et al.
    Many experimentally identified microRNA-binding sites are ineffective at mediating repression, and an improved quantitative model for predicting the effective sites is as informative as high-throughput experimental approaches.
    1. Cell Biology
    2. Evolutionary Biology

    TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants

    Michael Sulak et al.
    Elephants escaped enhanced cancer susceptibility by evolving more master tumor suppressor genes.
    1. Microbiology and Infectious Disease

    Species specific differences in use of ANP32 proteins by influenza A virus

    Jason S Long et al.
    Chicken ANP32A, and not chicken ANP32B, supports influenza polymerase activity and thus editing of this single gene may generate chickens that are resilient to influenza virus infection.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Functional trade-offs and environmental variation shaped ancient trajectories in the evolution of dim-light vision

    Gianni M Castiglione, Belinda SW Chang
    The evolution of the light-sensitive visual pigment rhodopsin involved functional tradeoffs that may have sacrificed rod photosensitivity for active-state protein stability to mitigate phototoxicity in tetrapods, but not in fishes.

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