1,433 results found
    1. Genetics and Genomics

    Genetic Variation: Searching for solutions to the missing heritability problem

    Luisa F Pallares
    Rare genetic variants in yeast explain a large amount of phenotypic variation in a complex trait like growth.
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    1. Computational and Systems Biology
    2. Genetics and Genomics

    Genetic effects on promoter usage are highly context-specific and contribute to complex traits

    Kaur Alasoo et al.
    Re-analysis of large gene expression datasets with state-of-the-art quantification methods reveals additional candidate genes mediating complex trait associations.
    1. Genetics and Genomics

    Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage

    Angela Schulz et al.
    Genetic and functional studies reveal a previously unrecognized role for a transmembrane protein in glomerular filtration barrier function.
    1. Human Biology and Medicine

    Integrative genomic analysis of the human immune response to influenza vaccination

    Luis M Franco et al.
    By comparing gene expression in people before and after they received the influenza vaccine, researchers were able to identify genes that contribute to differences in individual responses to vaccination.
    1. Genetics and Genomics

    Rare variants contribute disproportionately to quantitative trait variation in yeast

    Joshua S Bloom et al.
    Rare, evolutionarily recent variants have larger effect sizes and are more likely to decrease fitness, providing evidence that quantitative traits in yeast have evolved under purifying selection.
    1. Computational and Systems Biology

    Linking traits based on their shared molecular mechanisms

    Yael Oren et al.
    Systematic analysis of a broad spectrum of behavioral and physiological traits reveals novel relationships among complex traits, and resolves their underlying combination of genetic loci and molecular mechanisms.
    1. Human Biology and Medicine

    Human Genetics: Immune response is a personal matter

    Pedro G Ferreira, Emmanouil T Dermitzakis
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    1. Genetics and Genomics

    Polygenic Scores: It is time to get real when trying to predict educational performance

    Cecile Janssens
    A study of 3,500 children in the UK shows that data on socioeconomic background and previous educational achievements can better predict how students will perform at school than genetic data.
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    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Epigenetics: A memory of longevity

    Felicity Emerson et al.
    Worms with increased levels of the epigenetic mark H3K9me2 have a longer lifespan that can be passed down to future generations.
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