529 results found
    1. Neuroscience

    Experience-dependent weakening of callosal synaptic connections in the absence of postsynaptic FMRP

    Zhe Zhang et al.
    Postnatal, postsynaptic loss of FMRP specifically weakens callosal synaptic inputs onto L2/3 pyramidal neurons, in requirement ofnormal sensory experience, through downregulating AMPA receptor transmission and without affecting local synaptic inputs during cortical circuit development.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Competitive binding of MatP and topoisomerase IV to the MukB hinge domain

    Gemma LM Fisher et al.
    Topoisomerase IV and the ter-binding protein MatP competitively bind the hinge domain of the Escherichia coli Structural Maintenance of Chromosomes complex, MukB, leading to spatiotemporal regulation of MukBEF-topoisomerase IV activity.
    1. Cell Biology

    Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids

    Thomas M Rawlings et al.
    The study of embryo-endometrial interactions in assembloid co-cultures identifies novel mechanisms of reproductive failure.
    1. Neuroscience

    The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges

    Pierre-Luc Rochon et al.
    A novel retinal ganglion cell requires a cell adhesion molecule to grow its dendrites, collect synaptic inputs, and become selective to edges placed in its receptive field.
    1. Ecology

    A beta-glucosidase of an insect herbivore determines both toxicity and deterrence of a dandelion defense metabolite

    Meret Huber et al.
    An insect digestive enzyme metabolizes a plant defense compound and thereby modulates herbivore performance and host plant choice, which in turn may alter plant defense evolution in nature.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Filopodia powered by class x myosin promote fusion of mammalian myoblasts

    David W Hammers et al.
    Filopodia driven by class X myosin promote the fusion of mammalian myoblasts in the development of skeletal muscle and are important for the regeneration of skeletal muscle following muscle injury.
    1. Neuroscience

    Circadian regulation of vertebrate cone photoreceptor function

    Jingjing Zang et al.
    Circadian expression of cone visual transduction genes and corresponding proteins correlates with circadian changes in photoresponse kinetics and visual behavior, linking circadian gene expression with physiological and behavioral rhythmicity.
    1. Developmental Biology
    2. Neuroscience

    Unbiased identification of novel transcription factors in striatal compartmentation and striosome maturation

    Maria-Daniela Cirnaru et al.
    RNAseq and ATACseq are utilized to identify transcription factors participating in striatal compartmentation into striosome and matrix, and roles for Stat1, Olig2, and Foxf2 are validated in vitro and in vivo.
    1. Neuroscience

    Neural excitability and sensory input determine intensity perception with opposing directions in initial cortical responses

    Tilman Stephani et al.
    Larger evoked responses during initial cortical processing may reflect states of lower excitability.

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