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    1. Microbiology and Infectious Disease

    Human immunodeficiency virus-1 induces host genomic R-loops and preferentially integrates its genome near the R-loop regions

    Kiwon Park, Dohoon Lee ... Kwangseog Ahn
    Investigation of the role of triple-stranded nucleic acid, R-loops, in HIV-1 genome integration.
    1. Neuroscience

    Cortical neuroprosthesis-mediated functional ipsilateral control of locomotion in rats with spinal cord hemisection

    Elena Massai, Marco Bonizzato ... Marina Martinez
    Stimulation of the ipsilateral motor cortex after spinal cord injury activates bilateral motor synergy and restores hindlimb movement, advancing neuroprosthetic strategies for motor recovery.
    1. Immunology and Inflammation

    T-follicular helper cells are epigenetically poised to transdifferentiate into T-regulatory type 1 cells

    Josep Garnica, Patricia Sole ... Pere Santamaria
    T-regulatory type 1 cells inherit a broad repertoire of epigenetic marks from T-follicular helper T-cells, offering new insights into the developmental biology of this subset.
    1. Genetics and Genomics
    2. Evolutionary Biology

    The paradox of extremely fast evolution driven by genetic drift in multi-copy gene systems

    Xiaopei Wang, Yongsen Ruan ... Haijun Wen
    Revised
    Reviewed Preprint v2
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    1. Computational and Systems Biology
    2. Genetics and Genomics

    Functional characteristics and computational model of abundant hyperactive loci in the human genome

    Sanjarbek Hudaiberdiev, Ivan Ovcharenko
    Large-scale multi-omics analysis of genomic high-occupancy target regions in humans suggests involvement of large transcriptional condensates.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    PRR adjuvants restrain high stability peptides presentation on APCs

    Bin Li, Jin Zhang ... Chao Wu
    Adjuvants, MPLA and CpG especially, modulate the peptide repertoires presented on the surface of APCs, preferring the presentation of low-affinity exogenous peptides rather than high-affinity peptides.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Somatic mutation rates scale with time not growth rate in long-lived tropical trees

    Akiko Satake, Ryosuke Imai ... Masahiro Kasahara
    Long-lived tropical trees in Southeast Asia accumulate somatic mutations in a manner that is dependent on time, rather than growth rate.
    1. Neuroscience

    Operation regimes of spinal circuits controlling locomotion and the role of supraspinal drives and sensory feedback

    Ilya A Rybak, Natalia A Shevtsova ... Alain Frigon
    Spinal circuits performing speed- and context-dependent control of locomotion in mammals can operate in different regimes with prevailing role of central mechanisms, supraspinal signals, or sensory feedback.
    1. Genetics and Genomics

    An in vitro approach reveals molecular mechanisms underlying endocrine disruptor-induced epimutagenesis

    Jake D Lehle, Yu-Huey Lin ... John R McCarrey
    The utility of an in vitro cell culture system for studies of molecular mechanisms underlying the initial induction and subsequent propagation of environmentally induced epimutations is demonstrated.
    1. Neuroscience

    Cell-type-specific origins of locomotor rhythmicity at different speeds in larval zebrafish

    Moneeza A Agha, Sandeep Kishore, David L McLean
    Unexpected complexity in the synaptic basis of locomotor rhythmogenesis is linked to cell type and speed in larval zebrafish.