Styxl2, a sarcomeric muscle-specific pseudophosphatase in vertebrates, functions in sarcomere assembly by promoting protein degradation of non-muscle myosin IIs.
Van Thien Chi Nguyen, Trong Hieu Nguyen ... Le Son Tran
SPOT-MAS (screening for the presence of tumor by methylation and size) is an affordable and effective multi-cancer early detection test analyzing multiple features of circulating tumor DNA.
A calcium-based mechanism of neural recruitment offers a biophysical framework that unifies recent findings on respiratory rhythm generation and pattern formation by the circuitry within the brainstem.
Amicia D Elliott, Adama Berndt ... Benjamin H White
The elementary units of a fruit fly behavioral sequence are described at single-muscle resolution and shown to exhibit variability that is subject to neuromodulatory regulation.
A combination of genetics, experimental evolution and mathematical modelling defines information necessary to predict the outcome of short-term adaptive evolution.
The phase of a neuron in an oscillatory network can remain independent of network frequency when synaptic input strength and peak phase are adjusted in a frequency-dependent manner.
Brian C Del Rosario, Andrea J Kriz ... Jeannie T Lee
The chromosome architectural protein, CTCF, is phosphorylated at Ser224 in a cell-cycle-dependent manner and abrogation of phosphorylation leads to a cell growth defect.
Sarah Elizabeth Albritton, Anna-Lena Kranz ... Sevinc Ercan
Gene regulatory elements can target a chromatin regulatory complex to a single chromosome in the genome through hierarchical specification and long distance cooperation.
Transport-based high-throughput identification of cargo proteins specific to all 12 human importin-β family nuclear import receptors revealed biological processes that the cargo cohorts of each receptor are involved in.
