8,271 results found
    1. Biochemistry and Chemical Biology

    Non-enzymatic primer extension with strand displacement

    Lijun Zhou et al.
    Relying on RNA fragments derived from degradation or partial template copying, non-enzymatic primer extension with strand displacement offers a novel and prebiotically plausible approach to RNA self-replication.
    1. Structural Biology and Molecular Biophysics

    Crystal structure of dopamine receptor D4 bound to the subtype selective ligand, L745870

    Ye Zhou et al.
    The structure of receptor-ligand complex reveals the ligand binding selectivity among different dopamine receptor subtypes and also shows how this ligand class inhibits receptor activity.
    1. Neuroscience

    A projection specific logic to sampling visual inputs in mouse superior colliculus

    Katja Reinhard et al.
    Transsynaptic viral tracing reveals that neurons in the superior colliculus employ projection specific rules to the sampling of retinal inputs, directing distinct visual features to different downstream targets.
    1. Microbiology and Infectious Disease

    Persistent Mycobacterium tuberculosis infection in mice requires PerM for successful cell division

    Ruojun Wang et al.
    PerM-mediated FtsB stabilization is essential for cell division of Mycobacterium tuberculosis during chronic but not acute mouse infections.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    A microtranslatome coordinately regulates sodium and potassium currents in the human heart

    Catherine A Eichel et al.
    Association of mRNA in discrete, cotranslational complexes regulates currents controlling excitability in human cardiomyocytes.
    1. Evolutionary Biology

    Selection on mutators is not frequency-dependent

    Yevgeniy Raynes, Daniel Weinreich
    Contrary to intuition that the evolutionary fate of mutation rate modifying alleles is frequency-dependent, neither the strength nor the sign of selection on modifiers depends on initial frequency.

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