Browse the search results

Page 2 of 973
    1. Neuroscience

    CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons

    Margherita Farina et al.
    Stationary dense-core vesicles depend on the CAPS-1 protein to fuse with the presynaptic membrane.
    1. Neuroscience
    2. Computational and Systems Biology

    Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning

    Rui Ponte Costa et al.
    Combined pre- and postsynaptically expressed long-term plasticity of neuronal connections improves sensory discrimination, and enables rapid relearning of previously encountered information.
    1. Neuroscience

    CREB overexpression in dorsal CA1 ameliorates long-term memory deficits in aged rats

    Xiao-Wen Yu et al.
    Behavioral, biochemical, and biophysical analyses show that age-related memory deficits can be rescued by directly overexpressing wild-type CREB.
    1. Cell Biology
    2. Developmental Biology

    Transdifferentiation mediated tumor suppression by the endoplasmic reticulum stress sensor IRE-1 in C. elegans

    Mor Levi-Ferber et al.
    IRE-1 manipulates tumor cell identity to restore apoptosis sensitivity and suppress an aggressive germline tumor in C. elegans.
    1. Structural Biology and Molecular Biophysics

    Molecular architecture of the 90S small subunit pre-ribosome

    Qi Sun et al.
    The nearly complete architecture of the gigantic 90S precursor of small ribosomal subunit is determined by cryo-EM.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Role of the pre-initiation complex in Mediator recruitment and dynamics

    Elisabeth R Knoll et al.
    Genome-wide recruitment of Mediator and Pol II is reduced in yeast lacking the Med2-Med3-Med15 tail module triad, and Mediator association with gene promoters depends on Pol II, Taf1, and TBP.
    1. Neuroscience

    Brain-wide cellular resolution imaging of Cre transgenic zebrafish lines for functional circuit-mapping

    Kathryn M Tabor et al.
    A new resource of transgenic zebrafish lines facilitates precise targeting of neuronal cell-types within the brain, supported by online software for visualizing transgene expression patterns.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis for the recognition of spliceosomal SmN/B/B’ proteins by the RBM5 OCRE domain in splicing regulation

    André Mourão et al.
    Interactions with Sm proteins can provide a way in which regulatory factors can modulate alternative splice site choices.
    1. Neuroscience

    Discriminative stimuli are sufficient for incubation of cocaine craving

    Rajtarun Madangopal et al.
    Stimuli signaling reward availability potentiate and control relapse for up to 300 days of abstinence following cocaine, but not food, self-administration in rats.
    1. Cell Biology
    2. Neuroscience

    Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3'-end processing

    Piergiorgio La Rosa et al.
    The RNA binding protein Sam68 links a key metabolic route to the neural stem cell fate in the developing mouse brain.