7 results found
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    A single-chain and fast-responding light-inducible Cre recombinase as a novel optogenetic switch

    Hélène Duplus-Bottin, Martin Spichty ... Gaël Yvert
    A single protein catalyzes site-specific DNA recombination upon blue-light illumination.
    1. Cancer Biology
    2. Cell Biology

    ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin polymerization

    Katarzyna Bogucka-Janczi, Gregory Harms ... Krishnaraj Rajalingam
    ERK3 controls actin cytoskeleton.
    1. Developmental Biology
    2. Genetics and Genomics

    Cre/lox regulated conditional rescue and inactivation with zebrafish UFlip alleles generated by CRISPR-Cas9 targeted integration

    Fang Liu, Sekhar Kambakam ... Maura McGrail
    A novel strategy to create genetic mosaics in zebrafish for cell type-specific analysis of gene function that can be applied to any gene of interest.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Crk proteins transduce FGF signaling to promote lens fiber cell elongation

    Tamica N Collins, Yingyu Mao ... Xin Zhang
    Crk proteins are critical mediators of FGF signaling to control cell shape changes.
    1. Cell Biology
    2. Developmental Biology

    Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance

    Mannu K Walia, Patricia MW Ho ... Carl R Walkley
    The loss of p53 in bone cells activates critical signaling pathways; these are also essential in bone cancer.
    1. Neuroscience

    Differential effects of light and feeding on circadian organization of peripheral clocks in a forebrain Bmal1 mutant

    Mariko Izumo, Martina Pejchal ... Joseph S Takahashi
    Conditional deletion of Bmal1 in the forebrain/SCN reveals an essential role of a functional master clock in maintaining synchronized and high amplitude rhythms of peripheral clocks.
    1. Physics of Living Systems

    Salmonids elicit an acute behavioral response to heterothermal environments

    Robert Naudascher, Stefano Brizzolara ... Roman Stocker
    Not revised
    Reviewed Preprint v1

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