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    1. Neuroscience

    Control of neurotransmitter release by two distinct membrane-binding faces of the Munc13-1 C1C2B region

    Marcial Camacho, Bradley Quade ... Christian Rosenmund
    Two different binding modes of the Munc13-1 C­1C2B region govern synaptic vesicle priming and neurotransmitter release probability.
    1. Cell Biology
    2. Evolutionary Biology

    TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants

    Michael Sulak, Lindsey Fong ... Vincent J Lynch
    Elephants escaped enhanced cancer susceptibility by evolving more master tumor suppressor genes.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes

    Steffen Preissler, Claudia Rato ... David Ron
    Regulation of the endoplasmic reticulum chaperone BiP by calcium.
    1. Epidemiology and Global Health
    2. Medicine

    Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to initiating a first-in-human trial

    Manoj M Lalu, Katrina J Sullivan ... Lauralyn McIntyre
    A rigorous and transparent evaluation of mesenchymal stem cell therapy for sepsis suggests it may be efficacious, although the strength of these findings is tempered by threats to validity in the studies that were included.
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