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    1. Developmental Biology
    2. Evolutionary Biology

    Developmental hourglass and heterochronic shifts in fin and limb development

    Koh Onimaru, Kaori Tatsumi ... Shigehiro Kuraku
    Omics approaches reveal conserved and diversified gene regulation between fin and limb development.
    1. Evolutionary Biology

    New light shed on the early evolution of limb-bone growth plate and bone marrow

    Jordi Estefa, Paul Tafforeau ... Sophie Sanchez
    A three-dimensional investigation of extinct-tetrapod limbs shows that even though bone elongation and blood-cell production are intimately related to mammal long bones, these functions actually appeared successively in tetrapod evolution.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    In-silico analysis of myeloid cells across the animal kingdom reveals neutrophil evolution by colony-stimulating factors

    Damilola Pinheiro, Marie-Anne Mawhin ... Kevin J Woollard
    In-silico modeling of gene and protein emergence reveals how colony-stimulating factors contributed to the evolution and functional adaptions observed in mammalian neutrophils.
    1. Evolutionary Biology

    Morphology: Too hip for two sacral vertebrae

    Michelle R Stocker
    A complex pelvic morphology has been discovered in the fossils of one of the largest crocodylians.
    Version of Record
    Insight
    1. Evolutionary Biology

    Giant extinct caiman breaks constraint on the axial skeleton of extant crocodylians

    Torsten M Scheyer, John R Hutchinson ... Marcelo R Sánchez-Villagra
    The giant caiman Purussaurus from the Miocene of Venezuela is the first recorded member of crown Crocodylia having three sacrals, thus breaking the otherwise strict vertebral constraint of the group.
    1. Developmental Biology

    Specialized impulse conduction pathway in the alligator heart

    Bjarke Jensen, Bastiaan J Boukens ... Vincent M Christoffels
    A specialized conduction pathway for the electrical impulse in the heart, previously thought to be associated with the endothermic mammals and birds only, is also present in the ectothermic crocodiles.
    1. Developmental Biology

    Evolution: The beat goes on

    Tobias Wang
    Why is the alligator heart so similar to the hearts of birds and mammals?
    Version of Record
    Insight