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    1. Microbiology and Infectious Disease

    Cryo-electron tomography reveals novel features of a viral RNA replication compartment

    Kenneth J Ertel et al.
    Cryo-electron tomography unveils striking new structural components of positive-strand virus RNA replication compartments, greatly advancing mechanistic insights into the structure, assembly, function and control of these critical complexes.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments

    Svetlana O Dodonova et al.
    A molecular model of the assembled COPI coat, determined by cryo-electron tomography of an in vitro reconstituted budding reaction, reveals details of interactions mediating coat assembly and shows the binding site of ArfGAP2.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis

    Nicholas R Ader et al.
    Correlative microscopy and electron cryo-tomography on apoptotic HeLa cells reveal remodeling of outer and inner mitochondrial membranes, Bax cluster ultrastructure and ATP synthase reorganization in ruptured mitochondria.
    1. Cell Biology

    Electron cryo-tomography reveals the subcellular architecture of growing axons in human brain organoids

    Patrick C Hoffmann et al.
    Combining cerebral organoid technology with cryo-correlative microscopy reveals the organization of cytoskeleton, membrane compartments, and protein synthesis machinery contributing to the rapid expansion of developing human axons.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The role of Cdc42 and Gic1 in the regulation of septin filament formation and dissociation

    Yashar Sadian et al.
    Imaging with electron microscopy and cryo-electron tomography reveals that competition between Cdc42 and Gic1 for the same subunit within septins controls the formation and breakdown of septin filaments.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    TRiC’s tricks inhibit huntingtin aggregation

    Sarah H Shahmoradian et al.
    Cryo-electron tomography reveals how a chaperone protein called TRiC reduces the ability of pathogenic mutant huntingtin proteins to form aggregates.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The presence and absence of periplasmic rings in bacterial flagellar motors correlates with stator type

    Mohammed Kaplan et al.
    A correlation between the periplasmic embellishment of the flagellar motor and its stator system type is described, motors with dual H+-dependent stator systems have one periplasmic ring formed by MotY.
    1. Cell Biology
    2. Physics of Living Systems

    Principles of self-organization and load adaptation by the actin cytoskeleton during clathrin-mediated endocytosis

    Matthew Akamatsu et al.
    An experimentally constrained multiscale mathematical model predicts that branched actin networks self-organize at endocytic sites and bend to produce force, which was verified with cryo-electron tomography of intact cells.
    1. Microbiology and Infectious Disease

    Visualization of the type III secretion mediated Salmonella–host cell interface using cryo-electron tomography

    Donghyun Park et al.
    Visualization of the type III secretion mediated Salmonella-host cell interface reveals the intact translocon and the profound remodeling of the host membrane at unprecedented resolution.
    1. Microbiology and Infectious Disease

    In situ imaging of bacterial outer membrane projections and associated protein complexes using electron cryo-tomography

    Mohammed Kaplan et al.
    Electron cryo-tomography reveals that bacteria can form structurally-diverse outer membrane extensions with various protein complexes associated with them.