822 results found
    1. Microbiology and Infectious Disease

    Structural basis for capsid recruitment and coat formation during HSV-1 nuclear egress

    Elizabeth B Draganova et al.
    Interactions were visualized between the nuclear egress complex from herpes simplex virus and a capsid protein that could promote nucleocytoplasmic translocation of the capsid in infected cells.
    1. Cell Biology

    Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface

    Abril Angélica Escamilla-Ayala et al.
    Super-resolution microscopy sets a new strategy to comprehend the membrane organization of γ-secretase at single complex resolution identifying nanodomain associations and its diffusion in situ in the living membrane.
    1. Cell Biology
    2. Physics of Living Systems

    The transition state and regulation of γ-TuRC-mediated microtubule nucleation revealed by single molecule microscopy

    Akanksha Thawani et al.
    Four αβ-tubulin dimers associate laterally on γ-TuRC to define the rate-limiting transition state for microtubule nucleation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations

    Lucas Farnung et al.
    The structure of the chromatin remodeller CHD4 bound to a nucleosome reveals differences to the known Chd1-nucleosome complex and maps cancer mutations.
    1. Structural Biology and Molecular Biophysics

    Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity

    Lukas M Langer et al.
    First structural view of a substrate-bound PIKK (PI3K-related-kinase) by cryo-EM explains phosphorylation specificity toward a short amino-acid motif shared across the PIKK family and rationalizes PIKK auto-inhibition by regulatory domain.
    1. Structural Biology and Molecular Biophysics

    Ciliate mitoribosome illuminates evolutionary steps of mitochondrial translation

    Victor Tobiasson, Alexey Amunts
    The ciliate mitoribosome structure provides new insights into the diversity of translation and its evolution.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Tgfβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration

    Deepak A Kaji et al.
    TGFß signaling regulates migration of tenogenic cells from Scx- and non-Scx lineages and is required for functional regeneration after neonatal tendon injury.
    1. Developmental Biology

    A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation

    André Dias et al.
    During vertebrate axial extension, the tail bud originates from the activation of a developmental module in a subset of axial progenitors, concurrent but different to gastrulation.

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