2,053 results found
    1. Developmental Biology
    2. Neuroscience

    Dentate gyrus development requires a cortical hem-derived astrocytic scaffold

    Alessia Caramello, Christophe Galichet ... Robin Lovell-Badge
    An astrocytic scaffold that depends on SOX9 guides embryonic neuronal progenitors toward the developing dentate gyrus.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Generation of vascularized brain organoids to study neurovascular interactions

    Xin-Yao Sun, Xiang-Chun Ju ... Zhen-Ge Luo
    A vessel and brain fusion organoid model provides a platform for the study of interactions between neuronal and non-neuronal components during brain development and functioning.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    A conserved filamentous assembly underlies the structure of the meiotic chromosome axis

    Alan MV West, Scott C Rosenberg ... Kevin D Corbett
    Meiotic chromosome axis 'core' proteins from fungi, plants, and mammals form a conserved filament architecture, and use a common mechanism to recruit HORMAD proteins for meiotic recombination control.
    1. Developmental Biology

    A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation

    André Dias, Anastasiia Lozovska ... Moises Mallo
    During vertebrate axial extension, the tail bud originates from the activation of a developmental module in a subset of axial progenitors, concurrent but different to gastrulation.
    1. Cell Biology

    Dysregulated Ca2+ signaling, fluid secretion, and mitochondrial function in a mouse model of early Sjögren’s disease

    Kai-Ting Huang, Larry E Wagner ... David I Yule
    In a mouse model of Sjogren's disease, mitochondrial function and Ca2+ signaling are disrupted resulting in altered coupling between Ca2+ release and Ca2+ activated Cl- channels and salivary gland hypofunction.
    1. Evolutionary Biology

    Regulated aggregative multicellularity in a close unicellular relative of metazoa

    Arnau Sebé-Pedrós, Manuel Irimia ... Iñaki Ruiz-Trillo
    The transition to the aggregative stage of Capsaspora owczarzaki, a close unicellular relative to Metazoa, is associated with significant upregulation of orthologs of genes that are important for multicellularity in metazoans.
    1. Developmental Biology
    2. Structural Biology and Molecular Biophysics

    The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

    Elise S Bruguera, Jacob P Mahoney, William I Weis
    Biophysical binding and structural prediction studies reveal that Tetraspanin12 directly binds the ligand Norrin, in a manner that is negatively cooperative with Norrin-Fzd4 binding and competitive with Norrin-LRP5/6 binding.
    1. Computational and Systems Biology
    2. Developmental Biology

    A comprehensive model of Drosophila epithelium reveals the role of embryo geometry and cell topology in mechanical responses

    Mohamad Ibrahim Cheikh, Joel Tchoufag ... Konstantin Doubrovinski
    Direct mechanical microcantilever-based measurements establish key material parameters describing mechanical response of the early Drosophila embryonic epithelium.
    1. Developmental Biology

    Endocrine remodelling of the adult intestine sustains reproduction in Drosophila

    Tobias Reiff, Jake Jacobson ... Irene Miguel-Aliaga
    A hormone released after mating acts directly on adult intestinal progenitors and differentiated epithelial cells in Drosophila to change their homeostatic setpoint and maximise fecundity.
    1. Neuroscience

    KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization

    Rui Zheng, Yonglan Du ... Junyu Xu
    KIF2C plays an important role in synaptic plasticity and cognition behaviors in mice by regulating activity-dependent microtubule dynamic.

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