4 results found
    1. Chromosomes and Gene Expression

    Centromere deletion in Cryptococcus deuterogattii leads to neocentromere formation and chromosome fusions

    Klaas Schotanus, Joseph Heitman
    Centromere deletion in Cryptococcus deuterogattii results in neocentromeres, which span actively expressed genes and at elevated temperatures cen10∆ mutants are unstable leading to chromosome fusion and silencing of the neocentromere.
    1. Microbiology and Infectious Disease

    Natural mismatch repair mutations mediate phenotypic diversity and drug resistance in Cryptococcus deuterogattii

    R Blake Billmyre et al.
    Eukaryotic pathogens, like Cryptococcus deuterogattii, can use elevated mutation rates to more rapidly adapt to stresses, such as drug challenges, but at the cost of lower fitness in less stressful environments.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Synergistic and antagonistic drug interactions in the treatment of systemic fungal infections

    Morgan A Wambaugh et al.
    Identification and exploitation of interactions between the antifungal drug fluconazole and FDA- approved drugs has the potential to improve treatment for patients with difficult-to-treat systemic fungal infections.
    1. Genetics and Genomics

    Loss of centromere function drives karyotype evolution in closely related Malassezia species

    Sundar Ram Sankaranarayanan et al.
    The centromeres in Malassezia species, by breakage or inactivation, facilitate genome rearrangements that can result in varying karyotypes and contribute to the evolution of these species.

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