Meiosis and differentiation of basidium, a defining sexual structure of the phylum Basidiomycota, are genetically integrated by a shared regulatory program to ensure the formation of infectious meiospores in Cryptococcus neoformans.
Discovery of a novel mode of sexual reproduction, termed pseudosexual reproduction, in fungi where both parents are required for mating but only one contributes to the meiotic progeny, similar to hybridogenesis in animals.
Identification and exploitation of interactions between the antifungal drug fluconazole and FDA- approved drugs has the potential to improve treatment for patients with difficult-to-treat systemic fungal infections.
Eukaryotic pathogens, like Cryptococcus deuterogattii, can use elevated mutation rates to more rapidly adapt to stresses, such as drug challenges, but at the cost of lower fitness in less stressful environments.
Centromere deletion in Cryptococcus deuterogattii results in neocentromeres, which span actively expressed genes and at elevated temperatures cen10∆ mutants are unstable leading to chromosome fusion and silencing of the neocentromere.
Genome-wide chromatin mapping during bacterial-fungal cocultivation identifies the Myb-like transcription factor BasR as the major regulatory node of bacteria-triggered production of fungal secondary metabolites.