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The cryo-EM structure of the yeast Ctf3 complex enables near-atomic modeling of most Ctf19c/CCAN factors and their interactions.

Novel segmental chromosome amplifications in Candida albicans provide rapid adaptation to the most widely used antifungal drugs.

Proximity and homology guided inter-chromosomal translocations drive karyotype evolution.

An assay to assemble kinetochores de novo was developed and used to identify the role of the CENP-T pathway.

The cell cycle machinery regulates the assembly of the multi-protein kinetochore complex by targeting excess subunits for degradation via the proteasome.

Two components of the inner kinetochore (OA and Mif2) are independently capable of transmitting physiologically relevant forces to a centromeric nucleosome.

The chromosomal passenger complex interacts with the inner kinetochore COMA complex through the Ctf19 C-terminus in vitro which is shown to be important for mediating accurate chromosome segregation.

A stable tetrameric nucleosome occupies the central segment of each ∼120-bp budding yeast centromere in two rotational phases of both reflectional orientations in vivo.

Centromeric histones, the foundation for accurate chromosome segregation, have now been re-engineered to allow for analysis of the stoichiometry of required domains.

Reconstitution and cryo-EM reconstruction of the yeast Ctf19 complex (constitutive centromere associated network, or CCAN, in other organisms) shows how inner kinetochore proteins assemble.