87 results found
    1. Cell Biology

    Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids

    Thomas M Rawlings et al.
    The study of embryo-endometrial interactions in assembloid co-cultures identifies novel mechanisms of reproductive failure.
    1. Developmental Biology
    2. Neuroscience

    Activity-dependent modulation of synapse-regulating genes in astrocytes

    Isabella Farhy-Tselnicker et al.
    RNA sequencing and genetic mouse models reveal that transcriptional changes to astrocytes in the developing cortex are not intrinsic but influenced by their environment and determine that expression of astrocyte synapse-regulating genes and neuronal synaptogenesis is modulated by ongoing astrocyte-neuron communication.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The interplay of RNA:DNA hybrid structure and G-quadruplexes determines the outcome of R-loop-replisome collisions

    Charanya Kumar et al.
    Reconstitution of orientation-specific R-loop-replisome collisions with purified proteins reveals the differential impact of R-loop-associated RNA:DNA hybrids and G-quadruplexes on replication fork progression.
    1. Chromosomes and Gene Expression

    Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation

    Allison W McClure, John FX Diffley
    DNA replication fork rate in budding yeast is regulated in response to DNA damage by phosphorylation of two proteins, Mrc1 and Mcm10, by the Rad53 protein kinase.
    1. Cancer Biology

    Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness

    Haritha Mathsyaraja et al.
    The MYC transcription factor network member MGA is a subunit of a non-canonical Polycomb complex, which, when inactivated, accelerates tumorigenesis in mouse models of cancer and proliferation in colon organoids.
    1. Developmental Biology
    2. Physics of Living Systems

    Global constraints within the developmental program of the Drosophila wing

    Vasyl Alba et al.
    A novel mathematical strategy for the integrated analysis of adult body structures quantifies the degree and nature of developmental robustness and its evolutionary implications.
    1. Computational and Systems Biology

    A convolutional neural network for the prediction and forward design of ribozyme-based gene-control elements

    Calvin M Schmidt, Christina D Smolke
    Machine learning has been applied to develop predictive models for designing RNA gene-control elements with targeted gene-regulatory activities.
    1. Physics of Living Systems

    Robust, coherent, and synchronized circadian clock-controlled oscillations along Anabaena filaments

    Rinat Arbel-Goren et al.
    Noisy circadian clocks in Anabaena, coupled by cell-cell communication, display high spatio-temporal coherence and can be robustly described by incorporating demographic noise in a theoretical model of coupled clock arrays.
    1. Immunology and Inflammation
    2. Medicine

    Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death

    Jack Gisby et al.
    Severe COVID-19 is characterised by a plasma proteomic biomarker signature, indicating innate immune activation, leucocyte–endothelial interactions, and epithelial injury.
    1. Chromosomes and Gene Expression

    Promoter-specific changes in initiation, elongation, and homeostasis of histone H3 acetylation during CBP/p300 inhibition

    Emily Hsu et al.
    CBP/p300 acetylation of histone H3 at promoters and enhancers stimulates transcriptional elongation through recruitment of the super-elongation complex and BRD4.

Refine your results by:

Type
Research categories