352 results found
    1. Biochemistry and Chemical Biology

    Ctf4 organizes sister replisomes and Pol α into a replication factory

    Zuanning Yuan et al.
    Eukaryotic replisomes are strongly connected together to replicate both sister DNAs produced from a bidirectional origin.
    1. Structural Biology and Molecular Biophysics

    The structure of the yeast Ctf3 complex

    Stephen M Hinshaw et al.
    The cryo-EM structure of the yeast Ctf3 complex enables near-atomic modeling of most Ctf19c/CCAN factors and their interactions.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis

    Daniel M Cohen et al.
    The transcription factor C/EBPβ binds to different DNA sequences depending on whether it binds to ATF4, which enables C/EBPβ to conduct diverse transcriptional programs during adipocyte differentiation by exploiting an expanded motif repertoire.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis

    Shuping Zhang et al.
    The heme and HRI-mediated eIF2aP–ATF4 integrated stress response in erythropoiesis has a major global impact, especially under the stress condition of iron deficiency.
    1. Developmental Biology

    Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia

    Cheng Wang et al.
    Integrated stress response-induced expression of ATF4 and its transactivation of SOX9 causes aberrant chondrocyte differentiation and skeletal defects which can be alleviated by modulating initiation-factor eIF2α phosphorylation translation control.
    1. Cell Biology
    2. Neuroscience

    Cell Biology: Less translational control, more memory

    Graham D Pavitt
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    1. Genetics and Genomics
    2. Human Biology and Medicine

    Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell

    Eran Mick et al.
    Mitochondrial electron transport chain dysfunction triggers the integrated stress response due to an asparagine deficiency downstream of impaired NADH oxidation in proliferating myoblasts, but not in differentiated myotubes.
    1. Cell Biology
    2. Neuroscience

    Pharmacological brake-release of mRNA translation enhances cognitive memory

    Carmela Sidrauski et al.
    A compound that prevents stressors such as UV light and viral infection from downregulating protein synthesis inside cells improves memory performance in mice.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    E3 ubiquitin ligase Bre1 couples sister chromatid cohesion establishment to DNA replication in Saccharomyces cerevisiae

    Wei Zhang et al.
    E3 ubiquitin ligase Bre1-induced H2B monoubiquitination is epigenetically important for recruiting replication factor Mcm10 and cohesion establishment factors Ctf4, Ctf18 and Eco1 to early replication origins to establish sister chromatid cohesion.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response

    Xing-Huang Gao et al.
    ATF4, the master regulator of transcription during the Integrated Stress Response (ISR), causes global changes in cysteine sulfhydration of proteins and this event causes cellular metabolic reprogramming.

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