20 results found
    1. Plant Biology

    Compensatory sequence variation between trans-species small RNAs and their target sites

    Nathan R Johnson et al.
    Superfamilies of trans-species small RNAs from the parasitic plant Cuscuta have sequence variation that correspond to synonymous site variation in host plant target mRNAs.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub

    Sarah Louise Latty et al.
    The strength of Toll-like receptor signalling depends on the number and size of MyDDosomes formed as well as on how quickly these structures assemble.
    1. Biochemistry and Chemical Biology

    Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

    Rajendra Uprety et al.
    The structure-based design established a new approach to control pathway-selective activation of opioid receptors, resulting in new dual MOR/KOR G-protein biased agonist analgesics with attenuated liabilities.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells

    Miriam Stoeber et al.
    Chemically distinct opioid ligands promote selective protein recruitment by opioid receptors in intact cells.
    1. Neuroscience

    Tonic firing mode of midbrain dopamine neurons continuously tracks reward values changing moment-by-moment

    Yawei Wang et al.
    Although the phasic activity of midbrain dopamine neurons is known to represent reward values, these neurons displayed a tonic firing mode to continuously track reward values changing moment-by-moment.
    1. Ecology

    Humans disrupt access to prey for large African carnivores

    Kirby L Mills, Nyeema C Harris
    The presence of humans induces behavioral modifications in many large carnivore and ungulate species, restructuring spatiotemporal relationships between African predators and their prey.
    1. Ecology
    2. Genetics and Genomics

    Education and Outreach: March Mammal Madness and the power of narrative in science outreach

    Katie Hinde et al.
    Hypothetical battles between animals can be used to interest the general public in biology.
    1. Neuroscience

    Specialized contributions of mid-tier stages of dorsal and ventral pathways to stereoscopic processing in macaque

    Toshihide W Yoshioka et al.
    Visual area MT signals binocular disparity quickly and robustly, whereas area V4 or its upstream area transforms the nature of the signals to derive a more sophisticated depth representation.
    1. Neuroscience

    Task-dependent recurrent dynamics in visual cortex

    Satohiro Tajima et al.
    A decoding-based, state-space reconstruction reveals that neurons in macaque IT cortex change the structure of their collective attractor dynamics depending on task contexts.
    1. Ecology

    Mass enhances speed but diminishes turn capacity in terrestrial pursuit predators

    Rory P Wilson et al.
    Increased mass enhances speed but compromises turning capacity in pursuit predators; this has widespread ramifications for the best strategies for predators and prey during chases according to their relative masses.

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