955 results found
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA

    Swastik Phulera et al.
    Structure of the triheteromeric α1β1γ2S GABAA receptor in complex with GABA illuminates the principles of receptor assembly and agonist binding.
    1. Cell Biology
    2. Neuroscience

    CRELD1 is an evolutionarily-conserved maturational enhancer of ionotropic acetylcholine receptors

    Manuela D'Alessandro et al.
    The protein disulphide isomerase CRELD1 controls the biosynthesis of nicotinic acetylcholine receptors in nematode and mouse muscle.
    1. Structural Biology and Molecular Biophysics

    Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel

    Sandip Basak et al.
    Polyunsaturated fatty acids enhance desensitization in pentameric ligand-gated ion channels.
    1. Cell Biology
    2. Neuroscience

    2018 Gairdner Awards: The past, present and future of light-gated ion channels and optogenetics

    Sheena A Josselyn
    Research into light-gated ion channels called channelrhodospins laid the foundations for the development of optogenetics, a technique that has gone on to revolutionize neuroscience.
    1. Developmental Biology
    2. Neuroscience

    Developmental Neuroscience: Re-utilization of a transcription factor

    Filipe Pinto-Teixeira, Claude Desplan
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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit

    Ching-Ju Tsai et al.
    The structure of a light-sensitive G protein-coupled receptor in complex with a Gi-protein heterotrimer provides a structural foundation for the role of the receptor C-terminal tail in scaffolding and signaling.
    1. Neuroscience

    Presenilin/γ-secretase-dependent EphA3 processing mediates axon elongation through non-muscle myosin IIA

    Míriam Javier-Torrent et al.
    EphA signaling plays dual opposite roles on axon dynamics in neurons, so it inhibits and promotes axon growth through ligand binding and receptor processing, respectively.
    1. Cell Biology
    2. Human Biology and Medicine

    Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity

    Kasparas Petkevicius et al.
    Obesity leads to increased phosphatidylcholine turnover in adipose tissue macrophages that makes them susceptible to saturated fatty acid-induced inflammation.
    1. Neuroscience

    Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate

    Jordan N Norwood et al.
    Chemical ablation of olfactory sensory neurons blocks cerebrospinal fluid outflow into the nasal epithelium, leading to alterations of cerebrospinal fluid dynamics.
    1. Cancer Biology
    2. Cell Biology

    A positive feedback loop between Myc and aerobic glycolysis sustains tumor growth in a Drosophila tumor model

    Kenneth Kin Lam Wong et al.
    Specific molecular links that orchestrate growth signals and metabolic reprogramming to achieve tumorigenesis are identified as potential metabolic vulnerabilities in cancer treatment.

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