Delivery of Hedgehog, Decapentaplegic and Wingless to target cells in the Drosophila wing imaginal disc is regulated in both amount and destination, and is not dependent on constitutive release or uptake from a common pool.
Cells of the xanthophore lineage form projections that allow them to communicate with other pigment cells during adult pigment pattern formation in zebrafish, but not in the closely-related pearl danio.
Proteolysis of lipidated N-terminal peptides that tether Hedgehog morphogens to the surface of source cells is absolutely required for their coupled release and bioactivation in vivo in Drosophila melanogaster.
Wnt distribution is regulated by a dynamic exchange of its abundant scaffold-bound and rare freely diffusing populations, providing insights into a conceived dilemma of speed and stability of tissue patterning.
Eph receptor signaling commonly excludes migrating embryonic cells from regions of high ligand density; however, in sea urchin embryos pigmented immunocytes are attracted to regions expressing high levels of Ephrin.