The metabolite 2-hydroxybutyrate is an important aspect of exhaustion which leads to increased capacity in the branched chain amino acid degradation pathway.

Assessing metabolites in renal cell carcinoma and kidney tissue suggests cancers adapt rather than dictate nutrient availability.

Genetic analyses and biochemical studies show that JMJD6 promotes MYC-mediated transformation and is required for neuroblastoma growth by complexing with pre-mRNA splicing factors.

Multi-omics-driven patient stratification identify at-risk profile of metabolic complications in people living with HIV on suppressive therapy that need clinical attention.

For severe COVID-19 patients' red blood cells, healthy donor plasma reduces pathological red blood cell shape alterations and improves microcapillary flow in vitro through an interaction between red blood cells and plasma.

Animal models reveal that mitochondrial complex I is dispensable for homeostatic functions of the mouse liver.

Glutamine deprivation reprograms chondrocytes, attenuates inflammation, and such intervention may be protective against joint inflammation.

Multi-omic analyses reveal a connection between the integrated stress response and the regulation of redox and amino acid metabolism when the TCA cycle is impaired.

A project to repeat experiments from high-impact papers in cancer biology did not complete all replications, with challenges ranging from mundane reasons to unexpected methodological issues.