The yeast Saccharomyces cerevisiae has informed our understanding of molecular biology and genetics for decades, and learning more about its natural history could fuel a new era of functional and evolutionary studies of this classic model organism.
To leverage the tools, resources and knowledge that exist for C. elegans so that we can study ecology, evolution and other aspects of biology, we need to understand the natural history of this important model organism.
During centrosome maturation, pericentrin is delivered to the centrosome co-translationally by a microtubule- and dynein-dependent process, as pericentrin mRNA is undergoing active translation near the centrosome.
In naturalistic conditions, larvae of the Drosophila group exhibit species-specific strategies to search for food resources through a primitive form of risk-taking behavior that is controlled by a tradeoff between exploitation and odor-driven exploration.
Identification of tissue-specific RNA editing using a robust, publicly-available platform (SAILOR) reveals noncoding A-to-I editing events required for proper gene expression and neurological function, significantly advancing the understanding of how ADARs function in neural cells.
Transcription factors form clusters independently of the presence of DNA, which regulate target genes as opposed to individual monomers, addressing a longstanding question of how transcription factors can find gene targets so quickly.