Drosophila larvae manipulated by an automated system can be observed for 30+ hr, and new analysis methods of long-timescale trajectories reveal behavioral features previously inaccessible, such as a bimodal distribution of thermal navigation efficiency in individual animals.
Although odorant binding proteins are widely believed to be required for transport of odorants to receptors, six types of sensilla of Drosophila respond robustly in their absence to many odor stimuli.
Chu Hsien Lim, Prameet Kaur ... Nicholas S Tolwinski
An optogenetic approach has been developed to model Alzheimer's disease allowing light-induced Amyloid-β aggregation and tested in three model organisms, Drosophila, C. elegans and D. rerio.
Simranjot Bawa, David S Brooks ... Erika R Geisbrecht
TRIM32-mediated glycolytic flux generates precursors that are utilized for biomass production in non-dividing muscle, brain and tumor cells, demonstrating a universal metabolic function for TRIM32 in cell growth.
Pierre Khoueiry, Charles Girardot ... Eileen EM Furlong
Interspecies comparison of transcription factor occupancy during embryogenesis reveals potential co-operative relationships between factors and uncovers the inherent plasticity of developmental enhancers to overcome divergence in transcription factor occupancy.
Matthew A Cottee, Nadine Muschalik ... Susan M Lea
The structure of the Ana2 Central Coiled-Coil Domain provides insight into how centriolar cartwheel components may be recruited and assembled, and indicates that cartwheel assembly involves more than just SAS-6 oligomerisation.