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Page 4 of 191
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Development: Unlocking the microbiome

    Rosana BR Ferreira, L Caetano M Antunes
    Individual species of bacteria and yeast present in the food of wild fruit flies work together to provide the nutrients needed for larval growth.
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    1. Neuroscience
    2. Physics of Living Systems

    Continuous, long-term crawling behavior characterized by a robotic transport system

    James Yu, Stephanie Dancausse ... Mason Klein
    Drosophila larvae manipulated by an automated system can be observed for 30+ hr, and new analysis methods of long-timescale trajectories reveal behavioral features previously inaccessible, such as a bimodal distribution of thermal navigation efficiency in individual animals.
    1. Neuroscience

    Robust olfactory responses in the absence of odorant binding proteins

    Shuke Xiao, Jennifer S Sun, John R Carlson
    Although odorant binding proteins are widely believed to be required for transport of odorants to receptors, six types of sensilla of Drosophila respond robustly in their absence to many odor stimuli.
    1. Developmental Biology
    2. Neuroscience

    Application of optogenetic Amyloid-β distinguishes between metabolic and physical damages in neurodegeneration

    Chu Hsien Lim, Prameet Kaur ... Nicholas S Tolwinski
    An optogenetic approach has been developed to model Alzheimer's disease allowing light-induced Amyloid-β aggregation and tested in three model organisms, Drosophila, C. elegans and D. rerio.
    1. Microbiology and Infectious Disease

    Structure–function analysis of Lactiplantibacillus plantarum DltE reveals D-alanylated lipoteichoic acids as direct cues supporting Drosophila juvenile growth

    Nikos Nikolopoulos, Renata C Matos ... François Leulier
    D-alanylated lipoteichoic acids support Drosophila juvenile growth.
    1. Cancer Biology
    2. Cell Biology

    Drosophila TRIM32 cooperates with glycolytic enzymes to promote cell growth

    Simranjot Bawa, David S Brooks ... Erika R Geisbrecht
    TRIM32-mediated glycolytic flux generates precursors that are utilized for biomass production in non-dividing muscle, brain and tumor cells, demonstrating a universal metabolic function for TRIM32 in cell growth.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Uncoupling evolutionary changes in DNA sequence, transcription factor occupancy and enhancer activity

    Pierre Khoueiry, Charles Girardot ... Eileen EM Furlong
    Interspecies comparison of transcription factor occupancy during embryogenesis reveals potential co-operative relationships between factors and uncovers the inherent plasticity of developmental enhancers to overcome divergence in transcription factor occupancy.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies

    Matthew A Cottee, Nadine Muschalik ... Susan M Lea
    The structure of the Ana2 Central Coiled-Coil Domain provides insight into how centriolar cartwheel components may be recruited and assembled, and indicates that cartwheel assembly involves more than just SAS-6 oligomerisation.
    1. Neuroscience

    Classification and genetic targeting of cell types in the primary taste and premotor center of the adult Drosophila brain

    Gabriella R Sterne, Hideo Otsuna ... Kristin Scott
    A split-GAL4 collection provides precise genetic targeting of 138 neuronal cell types in the subesophageal zone of adult Drosophila melanogaster.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    A global change in RNA polymerase II pausing during the Drosophila midblastula transition

    Kai Chen, Jeff Johnston ... Julia Zeitlinger
    The first zygotic genes are transcribed without RNA polymerase II pausing from a TATA-enriched promoter.