The conserved biochemical activity of the duplicate Bab transcription factors were integrated into the regulatory hierarchy of an evolving gene regulatory network by binding site gains in a target gene's cis-regulatory region.
The insect dopaminergic system serves an important function in the regulation of ontogenesis and early development, contributing to the evolutionary processes that limit the ecological niche of Drosophila sechellia.
Interspecies comparison of transcription factor occupancy during embryogenesis reveals potential co-operative relationships between factors and uncovers the inherent plasticity of developmental enhancers to overcome divergence in transcription factor occupancy.
Drosophila melanogaster embryos undergo a dramatic genomic transformation in the hour preceding gastrulation, as thousands of promoters and regulatory regions become biochemically distinct before they become active.
Gene expression timing during Drosophila development is specified by multiple classes of RNA polymerase II core promoters, and the embryonic transcriptome includes thousands of evolutionarily conserved long noncoding RNAs.