59 results found
    1. Neuroscience

    Neuronal glutamate transporters control reciprocal inhibition and gain modulation in D1 medium spiny neurons

    Maurice A Petroccione, Lianna Y D'Brant ... Annalisa Scimemi
    The neuronal glutamate transporter EAAC1 limits excitation and lateral inhibition between D1-MSNs, which are important for the execution of slow-switching flexible behaviors.
    1. Neuroscience

    Neuromodulation of striatal D1 cells shapes BOLD fluctuations in anatomically connected thalamic and cortical regions

    Marija Markicevic, Oliver Sturman ... Nicole Wenderoth
    The structural characteristics of a circuit and its hierarchical dimensions are shown to influence regional time-series dynamics after targeted cellular-level manipulations.
    1. Neuroscience

    Excitation of medium spiny neurons by ‘inhibitory’ ultrapotent chemogenetics via shifts in chloride reversal potential

    Stephanie C Gantz, Maria M Ortiz ... Khaled Moussawi
    Modifying membrane potential by an 'inhibitory' chloride conductance such as PSAM4-GlyR is inherently unstable because the normally low intracellular concentration of chloride is readily increased by influx of chloride.
    1. Cell Biology
    2. Neuroscience

    The organic cation transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus

    Natasha M Puri, Giovanna R Romano ... Roshanak Irannejad
    Dopamine D1 receptor signaling from the Golgi apparatus in murine striatal medium spiny neurons is regulated by monoamine transporter OCT2.
    1. Neuroscience

    Cue- versus reward-encoding basolateral amygdala projections to nucleus accumbens

    Yi He, Yanhua H Huang ... Yan Dong
    Two distinct projections from the basolateral amygdala to nucleus accumbens differentially contribute to cue- versus reward-mediated behavioral reinforcement.
    1. Neuroscience

    Distinct representation of cue-outcome association by D1 and D2 neurons in the ventral striatum’s olfactory tubercle

    Nuné Martiros, Vikrant Kapoor ... Venkatesh N Murthy
    Real-time imaging of neural activity in behaving mice reveals that the two canonical types of neurons in the olfactory tubercle carry distinct information about learned odor cues, with D1 neurons representing stimulus valence and D2 neurons mainly representing stimulus identity.
    1. Neuroscience

    Complementary cognitive roles for D2-MSNs and D1-MSNs during interval timing

    Robert A Bruce, Matthew Weber ... Kumar Narayanan
    Dorsomedial D2-MSNs and D1-MSNs exhibit opposing dynamics during interval timing, however disrupting either MSN type produces similar effects on behavior, highlighting the complementary roles of striatal pathways in cognitive operations.
    1. Neuroscience

    Dopamine lesions alter the striatal encoding of single-limb gait

    Long Yang, Deepak Singla ... Sotiris C Masmanidis
    Striatal neurons preferentially fire at specific phases of the gait cycle, and the strength of gait encoding is selectively increased in indirect pathway neurons following dopamine lesions.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Losing Dnmt3a dependent methylation in inhibitory neurons impairs neural function by a mechanism impacting Rett syndrome

    Laura A Lavery, Kerstin Ure ... Huda Y Zoghbi
    Dnmt3a regulates gene expression in inhibitory neurons by writing all mCH and some mCG, and MeCP2 reads some of these mCH sites driving a portion of these gene expression changes.

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