9,130 results found
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Method development and characterisation of the low-molecular-weight peptidome of human wound fluids

    Mariena JA van der Plas et al.
    Peptidomics method development and analysis of qualitative differences of peptide patterns in human wound fluids provide potential biomarkers for wound healing and infection.
    1. Neuroscience
    2. Physics of Living Systems

    Revealing architectural order with quantitative label-free imaging and deep learning

    Syuan-Ming Guo et al.
    Advances in quantitative phase and polarized light microscopy, combined with deep learning, reveal the architecture of human brain tissue.
    1. Computational and Systems Biology
    2. Neuroscience

    On the objectivity, reliability, and validity of deep learning enabled bioimage analyses

    Dennis Segebarth et al.
    A comparison of different bioimage analysis pipelines reveals how deep learning can be used for automatized and reliable analysis of fluorescent features in biological datasets.
    1. Neuroscience

    DeepPoseKit, a software toolkit for fast and robust animal pose estimation using deep learning

    Jacob M Graving et al.
    A new deep-learning software toolkit with general-purpose methods for quickly and reliably measuring the full body posture of animals directly from images or videos without physical markers.
    1. Microbiology and Infectious Disease

    The kinetoplastid-infecting Bodo saltans virus (BsV), a window into the most abundant giant viruses in the sea

    Christoph M Deeg et al.
    Bodo saltans virus defines the most abundant giant viruses in the ocean and highlights the genomic plasticity, rooted in evolutionary arms races, that gave rise to giant viruses.
    1. Neuroscience

    Cold-induced hyperphagia requires AgRP neuron activation in mice

    Jennifer D Deem et al.
    A combination of neuroscience approaches and indirect calorimetry demonstrate a physiological role for AgRP neurons in cold-induced hyperphagia and strongly suggest temperature is an important regulator of AgRP neuron activity.
  1. Meta-Research: Journal policies and editors’ opinions on peer review

    Daniel G Hamilton et al.
    A survey of journals and editors in five areas of research - ecology, economics, medicine, physics and psychology - reveals a range of differences in their approach to peer review.
  2. Meta-Research: Large-scale language analysis of peer review reports

    Ivan Buljan et al.
    The linguistic characteristics of peer review reports are not influenced by research area, type of review or reviewer gender, which is evidence for the robustness of peer review.
    1. Cell Biology
    2. Immunology and Inflammation

    Deep-learning-based three-dimensional label-free tracking and analysis of immunological synapses of CAR-T cells

    Moosung Lee et al.
    Rapid, label-free, volumetric, and automated assessment of the immunological synapse dynamics is demonstrated by combining optical diffraction tomography and deep-learning-based segmentation, providing a new option for immunological research.
    1. Stem Cells and Regenerative Medicine

    Deep learning detects cardiotoxicity in a high-content screen with induced pluripotent stem cell-derived cardiomyocytes

    Francis Grafton et al.
    Deep learning combined with induced pluripotent stem cell technology is an effective method to interrogate cellular phenotypes and predict patterns of cardiotoxicity in vitro.

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