103 results found
    1. Genetics and Genomics

    Single cell functional genomics reveals the importance of mitochondria in cell-to-cell phenotypic variation

    Riddhiman Dhar et al.
    A genome-wide quantitative microscopy screen implicates mitochondria in single cell variation in proliferation and drug resistance in yeast.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Adaptation to mutational inactivation of an essential gene converges to an accessible suboptimal fitness peak

    João V Rodrigues, Eugene I Shakhnovich
    When an essential metabolic gene in E. coli is mutationally inactivated, subsequent evolution rarely reverts the mutation to wild type but rather follows unexpected paths that rewire metabolic fluxes.
    1. Neuroscience

    Coordinated control of terminal differentiation and restriction of cellular plasticity

    Tulsi Patel, Oliver Hobert
    Transcription factors that specify the identity of individual neuron types via activating terminal differentiation gene batteries also restrict cellular plasticity via altering the chromatin landscape.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate

    Natalie A Counihan et al.
    Plasmodium parasites secrete RhopH2 from the rhoptry organelle into their host red blood cell to facilitate the uptake of essential nutrients required for parasite replication and survival.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Eighteenth century Yersinia pestis genomes reveal the long-term persistence of an historical plague focus

    Kirsten I Bos et al.
    The analysis of 18th century Y. pestis genomes reveals a bacterial lineage that might be responsible for the 400-year period of European plague epidemics from the Renaissance through early modern times.
    1. Computational and Systems Biology

    RNA polymerase errors cause splicing defects and can be regulated by differential expression of RNA polymerase subunits

    Lucas B Carey
    A single human cell makes 10-100 transcriptional errors per second; these errors affect splicing and may influence the evolution of coding sequences.
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

    Jose U Scher et al.
    The sequencing of microbial genomes reveals that the presence of a particular microbial species in the gut may increase the risk of the autoimmune disease rheumatoid arthritis.
    1. Cell Biology
    2. Computational and Systems Biology

    Regulation of mRNA translation during mitosis

    Marvin E Tanenbaum et al.
    Ribosomal profiling reveals that translational repression is an important mechanism for cell cycle control and can complement protein degradation.
    1. Developmental Biology

    LncEGFL7OS regulates human angiogenesis by interacting with MAX at the EGFL7/miR-126 locus

    Qinbo Zhou et al.
    lncEGFL7OS is a lncRNA located at the EGFL7/miR-126 locus that is critical for angiogenesis in humans.

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