4 results found
    1. Neuroscience

    ERG-28 controls BK channel trafficking in the ER to regulate synaptic function and alcohol response in C. elegans

    Kelly H Oh et al.
    An endoplasmic reticulum membrane protein regulates synaptic transmission, alcohol sensitivity, and gene expression by controlling the trafficking of a calcium-activated potassium channel.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Hedgehog signaling is a potent regulator of liver lipid metabolism and reveals a GLI-code associated with steatosis

    Madlen Matz-Soja et al.
    The Hedgehog signalling pathway is a master regulator of lipid metabolic processes and their zonation in the adult liver of mice and humans.
    1. Cell Biology

    Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade

    Laurence Abrami et al.
    Cycles of palmitoylation-depalmitoylation by an upstream palmitoyltransferase allow precise tuning of DHHC6 activity, which in turn regulates the abundance and function of key ER proteins involved in protein folding, degradation, ER architecture and calcium homeostasis.
    1. Cell Biology
    2. Developmental Biology

    The novel SH3 domain protein Dlish/CG10933 mediates fat signaling in Drosophila by binding and regulating Dachs

    Yifei Zhang et al.
    The Fat-regulated scaffolding protein Dlish controls the activity, levels and cortical localization of Warts-inhibiting myosin Dachs by linking Dachs to a critical Dachs regulator, the DHHC palmitoyltransferase Approximated, and to the Fat-mediated regulation of Dachs stability.

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