150 results found
    1. Developmental Biology

    Homeodomain proteins hierarchically specify neuronal diversity and synaptic connectivity

    Chundi Xu, Tyler B Ramos ... Chris Q Doe
    The homeodomain protein Bsh increases lamina neuron types and visual function.
    1. Developmental Biology
    2. Neuroscience

    Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-α and Dpr10

    Lalanti Venkatasubramanian, Zhenhao Guo ... Richard S Mann
    Ig domain family members DIP-alpha and Dpr10 are required in a subset of Drosophila leg motor neurons and muscles, respectively, to establish their fine terminal branching pattern and synapses.
    1. Structural Biology and Molecular Biophysics

    Structural and thermodynamic analyses of the β-to-α transformation in RfaH reveal principles of fold-switching proteins

    Philipp K Zuber, Tina Daviter ... Stefan H Knauer
    The β-barrel conformation of the KOW domain of the metamorphic protein RfaH is in equilibrium with a low-populated, predominately unstructured state exhibiting helical elements, suggesting that transiently structured elements in unfolded conformations might be a general scheme in fold-switching proteins.
    1. Cell Biology

    High and stable ATP levels prevent aberrant intracellular protein aggregation in yeast

    Masak Takaine, Hiromi Imamura, Satoshi Yoshida
    The first demonstration that cellular ATP homeostasis suppresses high volatility of cellular ATP levels to ensure proteostasis that prevents accumulation of cytotoxic protein aggregation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Single molecule mechanics resolves the earliest events in force generation by cardiac myosin

    Michael S Woody, Donald A Winkelmann ... Yale E Goldman
    Cardiac myosin converts energy from ATP into mechanical work by transitioning from a short-lived force-bearing state, to a post working stroke state before the release of inorganic phosphate.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome

    An Van den Bossche, Steven W Hardwick ... Rob Lavigne
    A bacteriophage remodels the RNA metabolism machinery of a bacterial host to sequentially clear host transcripts and then stabilize the viral RNA.
    1. Neuroscience

    Distinct temporal difference error signals in dopamine axons in three regions of the striatum in a decision-making task

    Iku Tsutsui-Kimura, Hideyuki Matsumoto ... Mitsuko Watabe-Uchida
    Dopamine signals in the ventral, dorsomedial, and dorsolateral striatum are modulated by various variables, such as stimulus-associated value, choice, confidence, but these modulations can be inclusively explained by TD errors.
    1. Cell Biology
    2. Plant Biology

    Multi-functional roles for the polypeptide transport associated domains of Toc75 in chloroplast protein import

    Yamuna D Paila, Lynn GL Richardson ... Danny J Schnell
    The conserved polypeptide transport associated (POTRA) domains of the protein import channel, Toc75, are essential for protein import into chloroplasts.
    1. Structural Biology and Molecular Biophysics

    Designed α-sheet peptides inhibit amyloid formation by targeting toxic oligomers

    Gene Hopping, Jackson Kellock ... Valerie Daggett
    Novel designed alpha-sheet peptides inhibit amyloidosis in two different systems and preferentially bind the toxic oligomer.
    1. Neuroscience

    Human intracranial recordings link suppressed transients rather than 'filling-in' to perceptual continuity across blinks

    Tal Golan, Ido Davidesco ... Rafael Malach
    The brain ensures that blinks do not disrupt vision by deleting signals that represent discontinuities in visual input, rather than by recreating the missing input.

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