The intracellular location of a key sulfur compound, dimethylsulfoniopropionate, was identified in microalgae and its subsequent uptake by marine bacteria was quantified using a combination of secondary-ion mass-spectrometry techniques.
Endoplasmic reticulum proteostasis factors enhance the mutational tolerance of influenza hemagglutinin, a model secretory pathway protein and therapeutic target, particularly improving the fitness of temperature-sensitive variants.
Operonic mRNAs in bacteria are comprised of ORF (open reading frame)-wide units of secondary structure, which are intrinsically distinct between adjacent ORFs and encode a rough blueprint for ORF-specific translation efficiency.
While the basal ganglia have long been thought to mediate learning through dopamine-dependent striatal plasticity, their regulation of motor thalamus plays an unexpected and critical role in reinforcement.
Dorsomedial and dorsolateral striatal neural activity differ during early learning of action sequences but do not change with performance improvement across sessions, and become similar after extended training.
Genetic analysis of a CLN4 Drosophila model suggests that the disease-causing alleles act as dominant gain of function mutations that cause CSPα oligomerization and impair secretory and prelysosomal trafficking.