3,255 results found
    1. Cell Biology
    2. Developmental Biology

    Reactivation of a developmental Bmp2 signaling center is required for therapeutic control of the murine periosteal niche

    Valerie S Salazar et al.
    A periosteal Bmp2 signaling center couples bone length to bone width during development and must be reactivated by clinical bone anabolic therapies to reduce fracture risk and accelerate fracture repair.
    1. Developmental Biology
    2. Neuroscience

    The cellular basis of mechanosensory Merkel-cell innervation during development

    Blair A Jenkins et al.
    Touch-sensitive neurons are patterned during mammalian skin development by placode-derived keratinocytes and Bone Morphogenetic Protein signaling.
    1. Cell Biology

    Electron cryo-tomography provides insight into procentriole architecture and assembly mechanism

    Sam Li et al.
    A detailed description of the structure of procentriole MT triplet by cryoET, along with its associated non-tubulin proteins and its assembly intermediates, reveals possible molecular mechanism for the procentriole assembly.
    1. Cell Biology
    2. Developmental Biology

    zGrad is a nanobody-based degron system that inactivates proteins in zebrafish

    Naoya Yamaguchi et al.
    The F-box/anti-GFP nanobody fusion protein zGrad depletes GFP-tagged proteins with spatial and temporal control in zebrafish.
    1. Neuroscience

    Long-term consequences of the absence of leptin signaling in early life

    Angela M Ramos-Lobo et al.
    A mouse model that grew without functional leptin receptors until adulthood reveals that early defects in leptin signaling lead to permanent metabolic and developmental problems.
    1. Neuroscience

    Ephrin-B3 controls excitatory synapse density through cell-cell competition for EphBs

    Nathan T Henderson et al.
    Competition between neurons for postsynaptic ephrin-B3 controls distribution of a limited pool of synapses and defines a novel trans-synaptic mechanism enabling neurons to set the number of synapses they receive.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    The modular mechanism of chromocenter formation in Drosophila

    Madhav Jagannathan et al.
    Cell biological study reveals the mechanism by which multiple satellite-DNA-binding proteins cooperate to form chromocenter to encapsulate the full complement of chromosomes.
    1. Developmental Biology

    Specification of diverse cell types during early neurogenesis of the mouse cerebellum

    John W Wizeman et al.
    Single-cell RNA sequencing resolves inter- and intra-population heterogeneity, identifies rare cell types, and reconstructs specification trajectories during early neurogenesis of the mouse cerebellum.
    1. Ecology

    The cuticular hydrocarbon profiles of honey bee workers develop via a socially-modulated innate process

    Cassondra L Vernier et al.
    Chemical nestmate recognition in honey bee colonies depends on an innate, socially modulated developmental process.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Pyrophosphate modulates plant stress responses via SUMOylation

    M Görkem Patir-Nebioglu et al.
    In vivo inhibition of SUMO activating E1-enzymes by pyrophosphate reveals a mode of integrating metabolism and stress tolerance that is conserved across kingdoms.

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