2,236 results found
    1. Computational and Systems Biology

    Building accurate sequence-to-affinity models from high-throughput in vitro protein-DNA binding data using FeatureREDUCE

    Todd R Riley et al.
    A biophysically principled algorithm can build quantitative models of protein-DNA binding specificity of unprecedented accuracy from a leading type of high-throughput in vitro binding data.
    1. Developmental Biology

    Response to Nodal morphogen gradient is determined by the kinetics of target gene induction

    Julien Dubrulle et al.
    A kinetic model of morphogen interpretation is more suitable than classic threshold or ratchet models to understand how a signal gradient generates different target gene expression patterns.
    1. Biochemistry and Chemical Biology

    How to measure and evaluate binding affinities

    Inga Jarmoskaite et al.
    Simple guidelines and a checklist are provided for performing high-quality equilibrium binding measurements.
    1. Microbiology and Infectious Disease

    Single cell, super-resolution imaging reveals an acid pH-dependent conformational switch in SsrB regulates SPI-2

    Andrew Tze Fui Liew et al.
    Inside the acidic vacuole, expression, DNA binding and DNA binding affinity of the Salmonella regulator SsrB is stimulated by acid pH.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin

    Chao Yu Zhen et al.
    Live-cell single-molecule tracking reveals that hierarchical cooperation within the Polycomb Cbx7 protein between the low-affinity H3K27me3-binding module and the high-affinity DNA-binding cassette targets Polycomb repressive complex 1 to chromatin.
    1. Structural Biology and Molecular Biophysics

    Molecular Chaperones: Confirmation for conformational selection

    Yajun Jiang, Charalampos G Kalodimos
    NMR studies settle part of a long-standing debate about the mechanism used by the Hsp70 chaperone to recognize substrates.
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    1. Cell Biology
    2. Genetics and Genomics

    Retrotransposons: On the move

    Sandra L Martin
    The mechanisms by which a retrotransposon called LINE-1 duplicates itself and spreads through the human genome are becoming clearer.
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    1. Cancer Biology

    Oncogene Regulation: Enhancers not required

    Ying Zheng, David Levens
    Laboratory mice with over half a megabase of DNA upstream of their Myc gene removed still thrive in the absence of stress.
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    1. Cancer Biology
    2. Cell Biology

    Mathematical Modeling: Tuning the MYC response

    Ying Zheng, David Levens
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    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Translational Control: An emergency brake for protein synthesis

    Vladislava Hronová, Leoš Shivaya Valášek
    The integrated stress response is able to rapidly shut down the synthesis of proteins in eukaryotic cells.
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