4,543 results found
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Eya2 promotes cell cycle progression by regulating DNA damage response during vertebrate limb regeneration

    Konstantinos Sousounis et al.
    Experimental manipulation of a core DNA damage response factor and cell-cycle checkpoint regulators reveals a key role for these processes in the progenitor cells that fuel limb regeneration.
    1. Immunology and Inflammation

    A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages

    Abigail J Morales et al.
    Activated macrophages initiate a robust DNA damage response that depends on type I IFN and regulates their genetic program and inflammasome activation, establishing a mechanistic link between DNA damage responses and innate immunity.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Spatial and temporal organization of RecA in the Escherichia coli DNA-damage response

    Harshad Ghodke et al.
    Phase separated DNA-free stored forms of RecA dissolve in response to DNA damage to make RecA available for repair and recombination reactions as part of the bacterial (Escherichia coli) SOS response.
    1. Cell Biology

    Bacterial fumarase and L-malic acid are evolutionary ancient components of the DNA damage response

    Esti Singer et al.
    The dual function of an ancient prokaryotic enzyme, which is linked to specific metabolite signals, may have been the evolutionary driving force behind its dual localization in eukaryotes.
    1. Cancer Biology
    2. Cell Biology

    IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation

    Li Pan et al.
    Unbiased analyses highlight context-specific crosstalk between Notch, DNA damage response genes, and PP2A, and provide a roadmap for understanding how Notch induces squamous cell differentiation.
    1. Cell Biology

    The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage

    Owen A Brady et al.
    Disruption of TFEB and TFE3 results in diminished p53 signaling capacity and altered cell cycle regulation under genotoxic stress conditions.
    1. Biochemistry and Chemical Biology

    Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice

    Fanbiao Meng et al.
    SIRT1 deacetylates SIRT6 at K33 to facilitate DNA double-strand breaks-recognition, subsequent expansion and local chromatin remodeling.
    1. Cell Biology
    2. Evolutionary Biology

    TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants

    Michael Sulak et al.
    Elephants escaped enhanced cancer susceptibility by evolving more master tumor suppressor genes.
    1. Genetics and Genomics

    Parallel CRISPR-Cas9 screens clarify impacts of p53 on screen performance

    Anne Ramsay Bowden et al.
    The protein p53 negatively impacts the ability of a CRISPR screen to discriminate between essential and non-essential genes, hence, p53 status should be considered in these screens.
    1. Cancer Biology

    Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation

    Kai Fu et al.
    The nuclear protein Sam68 plays a role in the genotoxic stress-initiated "nuclear to cytoplasmic" activation of NF-κB and is involved in the development and survival of colon cancer.

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