3,120 results found
    1. Cell Biology

    DNA damage induces nuclear actin filament assembly by Formin-2 and Spire-1/2 that promotes efficient DNA repair

    Brittany J Belin et al.
    An efficient response to DNA damage requires the assembly of actin filaments in the nucleus.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Spatial and temporal organization of RecA in the Escherichia coli DNA-damage response

    Harshad Ghodke et al.
    Phase separated DNA-free stored forms of RecA dissolve in response to DNA damage to make RecA available for repair and recombination reactions as part of the bacterial (Escherichia coli) SOS response.
    1. Biochemistry and Chemical Biology

    Serine is the major residue for ADP-ribosylation upon DNA damage

    Luca Palazzo et al.
    Serine residues in proteins are the primary targets for PARP-dependent ADP-ribosylation signalling upon DNA damage.
    1. Immunology and Inflammation

    A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages

    Abigail J Morales et al.
    Activated macrophages initiate a robust DNA damage response that depends on type I IFN and regulates their genetic program and inflammasome activation, establishing a mechanistic link between DNA damage responses and innate immunity.
    1. Developmental Biology

    Germ cell connectivity enhances cell death in response to DNA damage in the Drosophila testis

    Kevin L Lu, Yukiko M Yamashita
    Genetic and cell biological study indicates that germ cells' connectivity serves as a mechanism to increase the sensitivity of germline to DNA damage, protecting the genome of gametes, in the Drosophila testis.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

    Nicolas Bigot et al.
    Two phosphorylation sites on 53BP1 are found to mediate interaction with TOPBP1-RAD9 and shown to be essential for assembling the G1 DNA damage checkpoint response apparatus.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization

    Stephanie J Papp et al.
    The circadian clock proteins, cryptochrome 1 (Cry1) and 2 (Cry2), evolved from bacterial light-activated DNA repair enzymes to detect DNA damage and coordinate the gene expression response.
    1. Microbiology and Infectious Disease

    Parvovirus minute virus of mice interacts with sites of cellular DNA damage to establish and amplify its lytic infection

    Kinjal Majumder et al.
    Development of a generally adaptable conformational capture assay for use in-trans identifies the specific direct interaction sites between the parvovirus minute virus of mice and the cellular genome during infection as sites of cellular DNA damage.
    1. Chromosomes and Gene Expression

    Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage

    Caroline Townsend Stork et al.
    The transcriptional response elicited by the hormone estrogen leads to DNA double-strand breaks by promoting R-loop formation in breast cancer cells.
    1. Cell Biology

    The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage

    Owen A Brady et al.
    Disruption of TFEB and TFE3 results in diminished p53 signaling capacity and altered cell cycle regulation under genotoxic stress conditions.

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