387 results found
    1. Developmental Biology
    2. Genetics and Genomics

    In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse

    Marco Morselli et al.
    DNA methylation deposition is dependent on the presence of H3K4me3 and H3K36me3 histone marks.
    1. Developmental Biology

    Epigenetic regulation of hematopoiesis by DNA methylation

    Aniket V Gore et al.
    Methylation of a key transcription factor gene by a de novo DNA methyltransferase assures the maintenance of hematopoietic stem cell fate.
    1. Genetics and Genomics
    2. Plant Biology

    Stress induced gene expression drives transient DNA methylation changes at adjacent repetitive elements

    David Secco et al.
    Phosphate starvation in rice induces widespread, but transient, modulation of DNA methylation near stress responsive genes that is independent from the RNA-directed DNA methylation pathway.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis

    Romeo Papazyan et al.
    A previously unappreciated histone methylation pathway helps limit DNA double-strand break formation and recombination in heterochromatin during meiosis.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    DNA methylation directs genomic localization of Mbd2 and Mbd3 in embryonic stem cells

    Sarah J Hainer et al.
    Two methyl-binding domain proteins have interdependent functions in embryonic stem cells, and this interdependency extends to the DNA methylation/hydroxymethylation machinery.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    An epigenetic switch ensures transposon repression upon dynamic loss of DNA methylation in embryonic stem cells

    Marius Walter et al.
    The various transposon families of the mammalian genome can adopt different types of repressive chromatin responses upon DNA methylation loss.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells

    João D Dias et al.
    Lysine mono- and di-methylation are two novel post-translational modifications of RNA polymerase II, which are enriched at promoters of active genes, precede lysine acetylation and mark early stages of transcription.
    1. Genetics and Genomics
    2. Plant Biology

    DNA methylation in Arabidopsis has a genetic basis and shows evidence of local adaptation

    Manu J Dubin et al.
    The adaptation of Arabidopsis plants to the local environment is linked to DNA methylation.
    1. Developmental Biology

    A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

    Meng Amy Li et al.
    A novel lncRNA (Ephemeron) is connected to known post-transcriptional and epigenetic regulators as part of an integrated machinery, which controls the timely exit from the naïve state of mouse embryonic stem cells.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    DNA methylation presents distinct binding sites for human transcription factors

    Shaohui Hu et al.
    A comprehensive study of human transcription factors reveals that a greater number of these proteins bind to methylated DNA sequences than previously thought.

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