4,859 results found
    1. Chromosomes and Gene Expression

    High-resolution mapping of heteroduplex DNA formed during UV-induced and spontaneous mitotic recombination events in yeast

    Yi Yin et al.
    Genome-wide mapping of heteroduplex DNA (a recombination intermediate) formed during mitotic recombination in yeast demonstrates that the "classical" model of double-strand DNA break repair is inadequate to explain several aspects of mitotic recombination.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Structural snapshots of Xer recombination reveal activation by synaptic complex remodeling and DNA bending

    Aleksandra Bebel et al.
    DNA-bound crystal structures of an essential Xer site-specific recombinase from the bacterium Helicobacter pylori reveal how large conformational changes initiate the untangling of chromosomes upon cell division.
    1. Chromosomes and Gene Expression

    DNA-RNA hybrids at DSBs interfere with repair by homologous recombination

    Pedro Ortega et al.
    Genetic and physical analyses reveal that DNA-RNA hybrids form fortuitously at DNA double-strand breaks during transcription and need removal to allow repair by homologous recombination.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation

    Martijn S Luijsterburg et al.
    A new mechanism is uncovered by which the RNF168 ubiquitin ligase couples PALB2-dependent homologous recombination to H2A ubiquitylation to promote DNA repair and preserve genome integrity.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Multiple interfaces between a serine recombinase and an enhancer control site-specific DNA inversion

    Meghan M McLean et al.
    The structure of the recombination complex responsible for flagellar antigen switching in Salmonella enterica, and the mechanism that regulates the site-specific DNA inversion reaction, have been determined.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    A novel motif of Rad51 serves as an interaction hub for recombination auxiliary factors

    Negar Afshar et al.
    Although Rad51 is the central protein involved in recombinational DNA repair, multiple auxiliary factors potentiate its activity by binding to a single, evolutionarily conserved motif.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Recombinational branch migration by the RadA/Sms paralog of RecA in Escherichia coli

    Deani L Cooper, Susan T Lovett
    The role of the bacterial protein RadA in homologous recombination – a DNA repair pathway vital to all cells – is defined.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Tiled-ClickSeq for targeted sequencing of complete coronavirus genomes with simultaneous capture of RNA recombination and minority variants

    Elizabeth Jaworski et al.
    Tiled-ClickSeq provides a simple and novel next-generation sequencing approach for complete genome sequencing of viruses including SARS-CoV-2, whilst capturing RNA recombination events and minority variants.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis

    Nicolas Altemose et al.
    In humans, specific sequence features can predict whether meiotic recombination occurs at sites bound by the protein PRDM9, whose DNA-binding zinc-finger domain can unexpectedly bind to gene promoters and to other copies of PRDM9.
    1. Chromosomes and Gene Expression

    The PCNA unloader Elg1 promotes recombination at collapsed replication forks in fission yeast

    Sanjeeta Tamang et al.
    Unloading the polymerase sliding clamp PCNA from DNA by Elg1 promotes recombination at the RTS1 replication fork barrier by limiting Fbh1 and Srs2 activity.

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