3,507 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels

    Lilia Leisle et al.
    Combined simulations and electrophysiological experiments show that the CLC channels and exchangers form physically distinct and evolutionarily conserved pathways through which Cl- and H+ ions move when crossing biological membranes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanisms of nucleotide selection by telomerase

    Matthew A Schaich et al.
    The roles of key telomerase active site residues were elucidated to determine how telomerase selects the correct from the incorrect nucleotide to maintain telomere integrity.
    1. Computational and Systems Biology
    2. Developmental Biology

    An image-based data-driven analysis of cellular architecture in a developing tissue

    Jonas Hartmann et al.
    A computational strategy for extracting representative numerical features from 3D microscopy data enables in-depth quantitative analysis of cell and tissue organization through machine learning-driven data integration and context-guided visualization.
  1. Blue and black pixels

    Episode 66: May 2020

    In this episode we hear about sparrows, cave-dwelling fish, COVID-19 in hospital staff, anti-fungal drugs and lack of insect diversity in soil.
    1. Developmental Biology
    2. Neuroscience

    Regulation of nerve growth and patterning by cell surface protein disulphide isomerase

    Geoffrey MW Cook et al.
    The nerve growth-repellent activity that generates spinal nerve repeat-patterning in birds and mammals is identified at the molecular level, and a similar system is revealed in adult brain grey matter.
    1. Neuroscience

    Functional specification of CCK+ interneurons by alternative isoforms of Kv4.3 auxiliary subunits

    Viktor János Oláh et al.
    Single cell RNA, protein and electrophysiology data revealed that combinatorial availability of three auxiliary subunit isoforms of a single ion channel is sufficient for generating distinct, input frequency-sensitive firing phenotypes.
    1. Developmental Biology
    2. Evolutionary Biology

    Evolutionary expansion of apical extracellular matrix is required for the elongation of cells in a novel structure

    Sarah Jacquelyn Smith et al.
    A new morphological structure evolved through extreme changes in cell height requires novel connections to an extracellular matrix network, which predates the origin of structure.
    1. Immunology and Inflammation

    Dithranol targets keratinocytes, their crosstalk with neutrophils and inhibits the IL-36 inflammatory loop in psoriasis

    Theresa Benezeder et al.
    Targeting the differentiation regulators and/or AMPs of keratinocytes, rather than targeting immune cells, may be an alternative approach for topical anti-psoriatic treatment, an area with high need for new drugs.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity

    Nairita Maitra et al.
    Extensive molecular profiling shows how loss of highly similar, paralogous ribosomal proteins lead to distinct phenotypic outputs, through translational control of specific mRNAs.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Retrocopying expands the functional repertoire of APOBEC3 antiviral proteins in primates

    Lei Yang et al.
    Genomes take advantage of the gene-duplicating ability of retroelements to birth novel innate immune defense genes.

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