3,464 results found
    1. Chromosomes and Gene Expression

    RNase H enables efficient repair of R-loop induced DNA damage

    Jeremy D Amon, Douglas Koshland
    In addition to causing DNA damage, R-loops cause genomic instability by interfering with DNA repair.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Evolution of extreme resistance to ionizing radiation via genetic adaptation of DNA repair

    Rose T Byrne et al.
    Experiments on E. coli show that multiple mechanisms contribute to extreme resistance to ionizing radiation in bacteria, with mutations to three genes for DNA repair having a prominent role in one evolved population.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Repair of naturally occurring mismatches can induce mutations in flanking DNA

    Jia Chen et al.
    The repair of spontaneous DNA damage can introduce mutators that lead to further genetic changes, which could underlie evolutionary change, disease and aging.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    CtIP forms a tetrameric dumbbell-shaped particle which bridges complex DNA end structures for double-strand break repair

    Oliver J Wilkinson et al.
    Structural and biochemical analysis of human CtIP provides new insights into DNA break recognition, binding and bridging during homologous recombination.
    1. Genetics and Genomics

    Mismatch repair deficiency endows tumors with a unique mutation signature and sensitivity to DNA double-strand breaks

    Hui Zhao et al.
    A comprehensive catalogue of somatic mutations accumulating in MMR-deficient tumors highlights their relevance in the context of human genetic evolution, for the diagnosis of microsatellite instability and the provision of targeted treatment options.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Covalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair

    Natasa Savic et al.
    Linking the DNA repair template to the Cas9 ribonucleoprotein complex enhances homology-directed repair of the induced DNA double strand break.
    1. Chromosomes and Gene Expression

    SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint

    Sílvia Carvalho et al.
    The involvement of SETD2 in an important DNA repair pathway could explain the high frequency of SETD2 mutations in several cancers and may provide an alternative mechanism to evade the p53-mediated checkpoint.
    1. Structural Biology and Molecular Biophysics

    Hexameric helicase G40P unwinds DNA in single base pair steps

    Michael Schlierf et al.
    Single-molecule FRET experiments reveal that G40P, a DnaB-like helicase, unwinds double-stranded DNA in single base pair steps and its processivity is enhanced by host primase DnaG.

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