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    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Ca2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon

    Salah A Baker et al.
    An optogenetic dual-color Ca2+-imaging approach shows how submucosal pacemaker-cells, interstitial cells of Cajal, modulate smooth-muscle responses and drive colonic motility via complex Ca2+ signaling.
    1. Genetics and Genomics
    2. Neuroscience

    Fruitless mutant male mosquitoes gain attraction to human odor

    Nipun S Basrur et al.
    Engineering male mosquitoes lacking the fruitless gene induces them to be attracted to humans.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Structure of dual BON-domain protein DolP identifies phospholipid binding as a new mechanism for protein localisation

    Jack Alfred Bryant et al.
    Analysis of the E. coli protein DolP reveals the first dual BON-domain structure and identifies phospholipid binding as a new mechanism for protein localisation to the outer membrane division site.
    1. Chromosomes and Gene Expression

    Checkpoint inhibition of origin firing prevents inappropriate replication outside of S-phase

    Mark C Johnson et al.
    The S-phase checkpoint has roles in all phases of the cell cycle, which has implications for the majority of cancers that lack cell cycle controls.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Mixed cytomegalovirus genotypes in HIV-positive mothers show compartmentalization and distinct patterns of transmission to infants

    Juanita Pang et al.
    Genomic analyses provide new insights into natural history and pathogenesis of cytomegalovirus infection and suggest new testable hypotheses that could be important for the design and implementation of new vaccines.
    1. Immunology and Inflammation

    Thymic stromal lymphopoietin limits primary and recall CD8+ T-cell anti-viral responses

    Risa Ebina-Shibuya et al.
    Immunological analysis of wild-type and Crlf2-/- mice reveals a role for the cytokine thymic stromal lymphopoietin on memory CD8+ T-cell responses to viral infection, findings with potential translational implications.
  1. Meta-Research: A retrospective analysis of the peer review of more than 75,000 Marie Curie proposals between 2007 and 2018

    David G Pina et al.
    A study of more than 75,000 grant proposals to the European Union indicates that the outcomes of the peer review process remain stable in response to changes in the way that peer review is organized.
    1. Stem Cells and Regenerative Medicine

    Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells

    John P Russell et al.
    Stem cells of the pituitary gland contribute to organ growth cell non-autonomously by promoting proliferation of committed progenitors through WNT ligand secretion.
    1. Medicine

    The gut microbiota is a transmissible determinant of skeletal maturation

    Abdul Malik Tyagi et al.
    The gut microbiota is a non-genomic, transmissible regulator of bone volume, structure, and turnover.