2,390 results found
    1. Cancer Biology

    Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells

    Bente Benedict et al.
    During tumorigenesis loss of p53 not only abrogates cell cycle arrest and apoptosis, but also suppresses the induction of replication-stress-induced DNA double-stranded breaks.
    1. Chromosomes and Gene Expression

    DNA Replication: A new role for a tumor-suppressing protein

    Jeremy S Setton, Simon N Powell
    In addition to its role in preventing tumors, the protein p53 appears to participate in a DNA repair process known as the replication-stress response.
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    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The interplay at the replisome mitigates the impact of oxidative damage on the genetic integrity of hyperthermophilic Archaea

    Tom Killelea et al.
    An investigation into 8-oxodeoxguanosine bypass by archaeal DNA polymerases.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Protein kinase C coordinates histone H3 phosphorylation and acetylation

    Zoulfia Darieva et al.
    Chromatin structure is altered following DNA replication stress through the activity of protein kinase C signalling which leads to functionally coupled histone H3 phosphorylation and acetylation events.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Nucleosomes influence multiple steps during replication initiation

    Ishara F Azmi et al.
    Nucleosomal DNAs assembled or modified by different chromatin remodeling enzymes differentially impact the origin licensing and helicase activation steps of replication initiation.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Cell Division: Turning cell cycle entry on its head

    Cosetta Bertoli, Robertus Antonius Maria de Bruin
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    1. Computational and Systems Biology

    Meta-Research: Incidences of problematic cell lines are lower in papers that use RRIDs to identify cell lines

    Zeljana Babic et al.
    The use of Research Resource Identifiers (RRIDs) improves the proper use of cell lines in the biomedical literature.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Plant-virus Interactions: Caught in a TrAP

    Delfina A Ré, Pablo A Manavella
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    1. Ecology
    2. Evolutionary Biology

    The Natural History of Model Organisms: New opportunities at the wild frontier

    Jane Alfred, Ian T Baldwin
    A better understanding of the natural history of model organisms will increase their value as model systems and also keep them at the forefront of research.

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