2,642 results found
    1. Cell Biology
    2. Computational and Systems Biology

    Transcriptional profiling reveals extraordinary diversity among skeletal muscle tissues

    Erin E Terry et al.
    There is no such thing as a representative skeletal muscle tissue, as each member of this family of tissues expresses a specialized mRNA program.
    1. Cell Biology

    Exportin Crm1 is repurposed as a docking protein to generate microtubule organizing centers at the nuclear pore

    Xun X Bao et al.
    Microtubule nucleation from the nuclear envelope in fission yeast involves repurposing of nuclear export proteins for a non-export-related function, docking cytoplasmic proteins at nuclear pore complexes.
    1. Cell Biology
    2. Human Biology and Medicine

    Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila

    Tom Cornelissen et al.
    Mitophagy occurs in Drosophila flight muscle and dopaminergic neurons in vivo and increases with aging in a PINK1/parkin-dependent fashion.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Neolithic and medieval virus genomes reveal complex evolution of hepatitis B

    Ben Krause-Kyora et al.
    Ancient hepatitis B virus (HBV) genomes were reconstructed from up to 7000-year-old Stone Age human skeletons, suggesting a long-time complex co-evolution with human populations.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly

    Hiroshi Yamaguchi et al.
    Zebrafish genetics and cryo-electron tomography reveal distinct roles of all vertebrate PIH family proteins in axonemal dynein assembly and cilia/flagella motions, assigning specific dynein subtypes to each PIH protein.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure

    Ian A Swinburne et al.
    The pressure of fluid in the inner ear is controlled by opening of cellular valves in the endolymphatic sac to allow for regulated transepithelial fluid flow.
    1. Immunology and Inflammation

    Plasmacytoid dendritic cells control dengue and Chikungunya virus infections via IRF7-regulated interferon responses

    Brian Webster et al.
    In vivo study of arbovirus infections reveals the dominant role of pDC IRF7-signaling in directing both type I and II IFN responses, and leading to viral control.
    1. Genetics and Genomics
    2. Evolutionary Biology

    Current CRISPR gene drive systems are likely to be highly invasive in wild populations

    Charleston Noble et al.
    If released in the wild, current CRISPR-based gene drive systems designed to alter populations could spread much farther than intended, despite the evolution of drive resistance.
    1. Microbiology and Infectious Disease

    Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut

    Aspen T Reese et al.
    Disturbing the microbiota with antibiotics alters gut redox state via changes in electron acceptor availability, setting the stage for post-antibiotic succession.
    1. Neuroscience

    Developmental deprivation-induced perceptual and cortical processing deficits in awake-behaving animals

    Justin D Yao, Dan H Sanes
    Developmental hearing loss causes perceptual deficits that are best explained by degraded auditory cortical encoding that is recorded during task performance.

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