Browse the search results

Page 2 of 585
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Opposing roles for DNA replication initiator proteins ORC1 and CDC6 in control of Cyclin E gene transcription

    Manzar Hossain, Bruce Stillman
    Two related DNA replication initiation proteins contribute to the decision of whether to enter a new round of the cell division cycle or enter into a period of proliferative quiescence.
    1. Structural Biology and Molecular Biophysics

    cryo-EM structures of the E. coli replicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease and τ

    Rafael Fernandez-Leiro et al.
    Structures of the replicative DNA polymerase Pol IIIα, the DNA sliding clamp, the proofreading exonuclease, and the processivity switch Tau (τ) suggest a mechanism for quick release during lagging strand synthesis.
    1. Chromosomes and Gene Expression

    Inter-Fork Strand Annealing causes genomic deletions during the termination of DNA replication

    Carl A Morrow et al.
    The discovery of a mechanism that causes DNA deletions during non-canonical DNA replication termination is described.
    1. Chromosomes and Gene Expression

    CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold

    Tom D Deegan et al.
    Ubiquitylation of the CMG helicase is inhibited throughout the initiation and elongation phases of chromosome replication by the DNA structure of a replication fork.
    1. Chromosomes and Gene Expression

    TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

    Remi Sonneville et al.
    The TRAIP ubiquitin ligase is required during mitosis to disassemble the replisome at sites of incomplete DNA replication, and activate the mitotic DNA repair pathway, thus preserving genome integrity.
    1. Microbiology and Infectious Disease

    Cryo-electron tomography reveals novel features of a viral RNA replication compartment

    Kenneth J Ertel et al.
    Cryo-electron tomography unveils striking new structural components of positive-strand virus RNA replication compartments, greatly advancing mechanistic insights into the structure, assembly, function and control of these critical complexes.
    1. Biochemistry and Chemical Biology

    Action of CMG with strand-specific DNA blocks supports an internal unwinding mode for the eukaryotic replicative helicase

    Lance Langston, Mike O’Donnell
    The CMG complex, the replicative helicase in eukaryotes, uses a different mechanism from bacterial and viral helicases by engaging both strands of parental DNA with substantial force and unwinding the duplex within the central channel of CMG.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Transposition-mediated DNA re-replication in maize

    Jianbo Zhang et al.
    Transposition reactions that occur during DNA replication and involve the termini of adjacent transposons can induce genome expansion by re-replication of transposon-flanking sequences.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    ATR/Mec1 prevents lethal meiotic recombination initiation on partially replicated chromosomes in budding yeast

    Hannah G Blitzblau, Andreas Hochwagen
    During meiosis, budding yeast use a checkpoint involving the protein Mec1 to prevent the formation of double-strand breaks in DNA that has not completed replication.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    DNA-mediated association of two histone-bound complexes of yeast Chromatin Assembly Factor-1 (CAF-1) drives tetrasome assembly in the wake of DNA replication

    Francesca Mattiroli et al.
    After DNA replication, nucleosomes are assembled by two histone chaperone complexes each bound to an H3-H4 histone dimer, suggesting the feasibility for a semi-conservative mode of epigenome inheritance.