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    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Frequent exchange of the DNA polymerase during bacterial chromosome replication

    Thomas R Beattie et al.
    DnaB Helicase is the only stable component of the bacterial replisome as the replicative DNA polymerase frequently exchanges in both leading and lagging strands.
    1. Cell Biology

    Two subunits of human ORC are dispensable for DNA replication and proliferation

    Etsuko Shibata et al.
    Human cell lines replicate and proliferate without ORC1 or ORC2, two subunits of the replication initiator protein complex ORC, which has till now been considered essential for DNA replication.
    1. Chromosomes and Gene Expression

    Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication

    FuJung Chang et al.
    Biochemical and genetic characterization of the Cdc6 replication initiator reveals similarities in the helicase loading reaction between bacteria and eukaryotes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Single-molecule studies contrast ordered DNA replication with stochastic translesion synthesis

    Gengjing Zhao et al.
    Competing DNA polymerases at the DNA sliding clamp are revealed by single-molecule co-localization studies.
    1. Chromosomes and Gene Expression

    Rapid DNA replication origin licensing protects stem cell pluripotency

    Jacob Peter Matson et al.
    The unique cell cycle variations of pluripotent stem cells ensures that the first step in DNA replication is particularly fast and this rapid rate, in turn, restrains early differentiation.
    1. Cell Biology

    DNA Replication: Rethinking origin licensing

    Stephen P Bell
    Human cells that lack a subunit in their origin recognition complex are viable, which suggests the existence of alternative mechanisms to initiate DNA replication.
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    1. Chromosomes and Gene Expression

    DNA Replication: A new role for a tumor-suppressing protein

    Jeremy S Setton, Simon N Powell
    In addition to its role in preventing tumors, the protein p53 appears to participate in a DNA repair process known as the replication-stress response.
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    1. Chromosomes and Gene Expression

    Multiple kinases inhibit origin licensing and helicase activation to ensure reductive cell division during meiosis

    David V Phizicky et al.
    Meiotic cells inhibit two distinct steps of replisome assembly with multiple kinases to prevent DNA replication between Meiosis I and Meiosis II.
    1. Cancer Biology

    Interferon alpha-inducible protein 6 regulates NRASQ61K-induced melanomagenesis and growth

    Romi Gupta et al.
    The protein IFI6 regulates DNA replication via the transcription factor E2F2, which is necessary for transformation and growth of melanomas induced by the NRASQ61K mutant oncogene product.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    MutSα maintains the mismatch repair capability by inhibiting PCNA unloading

    Yoshitaka Kawasoe et al.
    Biochemical analysis in Xenopus egg extracts reveals that the MutSα mismatch sensor retains the DNA-bound replication clamp to maintain a post-replicative temporal window permissive to strand-specific repair of mismatches.