153 results found
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Transposition-mediated DNA re-replication in maize

    Jianbo Zhang et al.
    Transposition reactions that occur during DNA replication and involve the termini of adjacent transposons can induce genome expansion by re-replication of transposon-flanking sequences.
    1. Chromosomes and Gene Expression

    Genomic DNA transposition induced by human PGBD5

    Anton G Henssen et al.
    The human PGBD5 gene encodes an active DNA transposase.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Target DNA bending by the Mu transpososome promotes careful transposition and prevents its reversal

    James R Fuller, Phoebe A Rice
    Biochemical data demonstrate that the conformation of the target site DNA can dramatically modulate the kinetics and directionality of the otherwise isoenergetic transposition reaction of DDE transposases.
    1. Structural Biology and Molecular Biophysics

    Casposase structure and the mechanistic link between DNA transposition and spacer acquisition by CRISPR-Cas

    Alison B Hickman et al.
    The tetrameric structure of a casposase bound to DNA and its biochemical properties show how a transposase could have evolved to perform CRISPR-Cas spacer acquisition.
    1. Biochemistry and Chemical Biology

    RNA-guided retargeting of Sleeping Beauty transposition in human cells

    Adrian Kovač et al.
    Fusion proteins composed of the Sleeping Beauty transposase and catalytically inactive Cas9 target transposon integration into genomic regions specified by single guide RNAs.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Transposase-assisted tagmentation of RNA/DNA hybrid duplexes

    Bo Lu et al.
    Tn5 transposase has direct tagmentation activity towards RNA/DNA hybrids, which is harnessed as a more convenient and faster RNA-seq library construction method and will benefit RNA and chromatin research.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Multiple serine transposase dimers assemble the transposon-end synaptic complex during IS607-family transposition

    Wenyang Chen et al.
    Genetic, structural, and biochemical analyses of IS607-family transposons shows that the DNA translocation reaction proceeds very differently from other reactions promoted by serine recombinases.
    1. Structural Biology and Molecular Biophysics

    A bend, flip and trap mechanism for transposon integration

    Elizabeth R Morris et al.
    Structural and biochemical analyses of a eukaryotic DNA transpososome in the integration step reveal how mariner/Tc1 transposons are selectively integrated into a TA target sequence.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Har-P, a short P-element variant, weaponizes P-transposase to severely impair Drosophila development

    Satyam P Srivastav et al.
    A female fertility syndrome in Drosophila called gonadal dysgenesis is caused by the P-transposase actively mobilizing a very short P-element variant that has been named the Har-P.
    1. Cancer Biology
    2. Genetics and Genomics

    Single-cell lineage tracing by endogenous mutations enriched in transposase accessible mitochondrial DNA

    Jin Xu et al.
    Epigenome and Mitochondrial Barcode of Lineage from Endogenous Mutations (EMBLEM) enable tracking cell lineage in combination with chromatin profile in ATAC-seq data.

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