1,004 results found
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Transposase-assisted tagmentation of RNA/DNA hybrid duplexes

    Bo Lu et al.
    Tn5 transposase has direct tagmentation activity towards RNA/DNA hybrids, which is harnessed as a more convenient and faster RNA-seq library construction method and will benefit RNA and chromatin research.
    1. Chromosomes and Gene Expression

    The homologous recombination machinery modulates the formation of RNA–DNA hybrids and associated chromosome instability

    Lamia Wahba et al.
    When a protein involved in DNA repair malfunctions, it can anneal RNA molecules to DNA molecules, creating hybrids that increase the frequency of mutations in the DNA.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi–Goutières syndrome

    Yoong Wearn Lim et al.
    Global epigenetic perturbations and accumulation of RNA:DNA hybrids are two novel hallmarks of the lupus-like inflammatory disorder Aicardi-Goutières syndrome.
    1. Chromosomes and Gene Expression

    DNA-RNA hybrids at DSBs interfere with repair by homologous recombination

    Pedro Ortega et al.
    Genetic and physical analyses reveal that DNA-RNA hybrids form fortuitously at DNA double-strand breaks during transcription and need removal to allow repair by homologous recombination.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Cisplatin-induced DNA double-strand breaks promote meiotic chromosome synapsis in PRDM9-controlled mouse hybrid sterility

    Liu Wang et al.
    The exogenous DNA DSBs improve meiotic chromosome pairing in mouse inter-subspecific hybrids, thus providing an evidence for a DSB-dependent mechanism of the PRDM9-controlled synapsis failure and infertility.
    1. Chromosomes and Gene Expression

    Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation

    Oscar Velazquez Camacho et al.
    An RNA-mediated mechanism that stabilizes association of the Suv39h enzymes at mouse heterochromatin is defined.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Sae2/CtIP prevents R-loop accumulation in eukaryotic cells

    Nodar Makharashvili et al.
    The CtIP DNA repair enzyme is required for the removal of transcription-associated lesions in eukaryotic cells.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Modulation of Prdm9-controlled meiotic chromosome asynapsis overrides hybrid sterility in mice

    Sona Gregorova et al.
    Prdm9-generated meiotic asynapsis of homologous chromosomes in mouse subspecific hybrids causes hybrid sterility and can be reversed by introducing random stretches of consubspecific sequence (≥ 27Mb) on four chromosomes most sensitive to asynapsis.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Archaeal TFEα/β is a hybrid of TFIIE and the RNA polymerase III subcomplex hRPC62/39

    Fabian Blombach et al.
    An archaeal basal transcription factor containing an iron-sulphur cluster sheds light on the evolution of transcription machineries in archaea and eukaryotes.
    1. Structural Biology and Molecular Biophysics

    Mechanisms of ribosome stalling by SecM at multiple elongation steps

    Jun Zhang et al.
    Nascent regulatory peptides tune the translation rate through a continuous, dynamic reshaping of the functional center of the ribosome.

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