Depletion of the mechanosensitive ion channel PEZO-1 in C. elegans disrupts the sheath and spermathecae cells to disrupt oocyte ovulation, resulting in crushed oocytes.

Multiple imaging modalities resolved the ultrastructure of single hematopoietic stem cells in their endogenous niche, allowing identification of dopamine beta-hydroxylase positive cells as a functional niche cell type.

Integrating multi-omics quantitative trait loci and genome-wide association study data into a multivariable Mendelian randomization framework allows to identify metabolite-mediated transcript-to-phenotype causal relations missed by methods focusing on a single omics layer.

Mediator, a transcriptional coactivator complex, is essential for transcription but is not a required component of a functional preinitiation complex, indicating that Mediator is not equivalent to a general transcription factor.

Functional molecular analysis of cytokinesis in Caenorhabditis elegans four-cell embryos reveals cell-type-specific variation in the fundamental dependence on a robust f-actin cytoskeleton for successful cell division, mediated by both cell-intrinsic and -extrinsic pathways.

Active zone release probability is correlated with calcium channel density and calcium influx at single release sites, with release strength increasing in an activity-dependent manner during synapse maturation.

Extraembryonic tissue spreading in the scuttle fly Megaselia abdita requires mechanical decoupling from the underlying yolk sac.

Genetic interaction and biochemical analyses have unveiled the crucial involvement of CTPS in the regulation of adipocyte growth, lipid metabolism, and metabolic adaptation in Drosophila, achieved through activating the PI3K-Akt-SREBP pathway.

Fungal hyphae constantly undergo signal oscillations, comparable to a cell 'monologue' until they meet another hypha with which they then coordinate signal oscillations and transit into a cell-to-cell dialogue.

Genetic analyses reveal the importance of dynamic protein processing at the apical cell membrane in response to forces damaging cell membranes during tube expansion in tubular organs.